PF 06726304 acetate
Tocris Bioscience, part of Bio-Techne | Catalog # 6169
Highly potent and SAM-competitive EZH2 inhibitor
Key Product Details
Description
Highly potent and SAM-competitive EZH2 inhibitor
Product Description
PF 06726304 acetate is a highly potent and SAM-competitive EZH2 lysine methyltransferase inhibitor (IC50 = 0.7 nM). Inhibits proliferation of Karpas-422 cells (non-Hodgkin's lymphoma) in vitro, and halts tumor growth and reduces intratumoral H3K27Me3 levels in mice.Licensing Information
Sold for research purposes under agreement from Pfizer Inc.Product Specifications
Molecular Weight
506.38
Formula
C22H21Cl2N3O3.C2H4O2
Storage
Store at RT
Purity
≥97% (HPLC)
Chemical Name
5,8-Dichloro-2-[(1,2-dihydro-4,6-dimethyl-2-oxo-3-pyridinyl)methyl]-7-(3,5-dimethyl-4-isoxazolyl)-3,4-dihydro-1(2H)-isoquinolinone acetate
CAS Number
2080306-28-9
PubChem ID
124201861
InChI Key
AVDCFFPRJKOOLX-UHFFFAOYSA-N
SMILES
ClC1=C(C(N(CC2=C(C)C=C(C)NC2=O)CC3)=O)C3=C(Cl)C=C1C4=C(C)ON=C4C.CC(O)=O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 50.64 | 100 | |
| Ethanol | 50.64 | 100 |
Preparing Stock Solutions
for PF 06726304 acetate
The following data is based on the product molecular weight 506.38
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.97 mL | 9.87 mL | 19.75 mL |
| 5 mM | 0.39 mL | 1.97 mL | 3.95 mL |
| 10 mM | 0.20 mL | 0.99 mL | 1.97 mL |
| 50 mM | 0.04 mL | 0.20 mL | 0.39 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Kung Design and synthesis of pyridone-containing 3,4-dihydroisoquinoline-1(2H)-ones as a novel class of enhancer of zeste homolog 2 (EZH2) inhibitors. J.Med.Chem. 2016 PMID: 27512831
Product Specific Notices for PF 06726304 acetate
For research use only
Loading...
Loading...