PF 06260933 dihydrochloride

Tocris Bioscience, part of Bio-Techne | Catalog # 5752

MAP4K4 (HGK) inhibitor; also inhibits MINK and TNIK
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Key Product Details

Description

MAP4K4 (HGK) inhibitor; also inhibits MINK and TNIK

View all Other MAPK Compounds »

Product Description

PF 06260933 dihydrochloride is a MAP4K4 (HGK) inhibitor (IC50 = 140 nM). Also inhibits MINK and TNIK (IC50 values are 8 and 13 nM, respectively). Improves fasting hyperglycemia in mice. Orally active.

Licensing Information

Sold for research purposes under agreement from Pfizer Inc.

Product Specifications

Molecular Weight

369.68

Formula

C16H13ClN4.2HCl

Storage

Desiccate at RT

Purity

≥98% (HPLC)

Chemical Name

5-(4-Chlorophenyl)-[3,3'-bipyridine]-6,6'-diamine dihydrochloride

CAS Number

1883548-86-4

PubChem ID

118701007

InChI Key

VRQXEOPUAQLBQI-UHFFFAOYSA-N

SMILES

NC1=NC=C(C3=CN=C(N)C=C3)C=C1C2=CC=C(Cl)C=C2.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 36.97 100
DMSO 7.39 20

Preparing Stock Solutions for PF 06260933 dihydrochloride

The following data is based on the product molecular weight 369.68

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.71 mL 13.53 mL 27.05 mL
5 mM 0.54 mL 2.71 mL 5.41 mL
10 mM 0.27 mL 1.35 mL 2.71 mL
50 mM 0.05 mL 0.27 mL 0.54 mL

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Background References

References are publications that support the biological activity of the product.

Product Documents for PF 06260933 dihydrochloride

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for PF 06260933 dihydrochloride

For research use only

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