PF 04628935
Tocris Bioscience, part of Bio-Techne | Catalog # 6347
Potent ghrelin receptor inverse agonist
Key Product Details
Description
Potent ghrelin receptor inverse agonist
Product Description
PF 04628935 is a potent ghrelin receptor inverse agonist (IC50 = 4.6 nM). Orally bioavailable and exhibits reasonable brain penetration.Licensing Information
Sold for research purposes under agreement from Pfizer Inc.Product Specifications
Molecular Weight
496.03
Formula
C24H26ClN7OS
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
1-[2-[[2-Chloro-4-(2H-1,2,3-triazol-2-yl)phenyl]methyl]-2,7-diazaspiro[3.5]non-7-yl]-2-(2-methylimidazo[2,1-b]thiazol-6-yl)ethanone
CAS Number
1383719-97-8
PubChem ID
70682037
InChI Key
MTDYDDJVCIHZKH-UHFFFAOYSA-N
SMILES
ClC1=C(CN2CC3(CCN(C(CC4=CN(C=C(C)S5)C5=N4)=O)CC3)C2)C=CC(N6N=CC=N6)=C1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 24.8 | 50 | |
| Ethanol | 9.92 | 20 |
Preparing Stock Solutions
for PF 04628935
The following data is based on the product molecular weight 496.03
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.5 mM | 4.03 mL | 20.16 mL | 40.32 mL |
| 2.5 mM | 0.81 mL | 4.03 mL | 8.06 mL |
| 5 mM | 0.40 mL | 2.02 mL | 4.03 mL |
| 25 mM | 0.08 mL | 0.40 mL | 0.81 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Kung Identification of spirocyclic piperidine-azetidine inverse agonists of the ghrelin receptor. Bioorg.Med.Chem.Lett. 2012 PMID: 22677316
Product Specific Notices for PF 04628935
For research use only
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