PF 04620110

Name: PF 04620110
Brand: Tocris Bioscience
SKU: 5863

Tocris Bioscience, part of Bio-Techne | Catalog # 5863

Citations (5)

COA / SDS

Potent and selective DGAT-1 inhibitor; orally bioavailable

Key Product Details

Description:	Potent and selective DGAT-1 inhibitor; orally bioavailable
Chemical Name:	trans-4-[4-(4-Amino-7,8-dihydro-5-oxopyrimido[5,4-f][1,4]oxazepin-6(5H)-yl)phenyl]cyclohexaneacetic acid
Purity:	≥98% (HPLC)
Molecular Weight:	396.44

View Full Technical Details for PF 04620110

Technical Data
Citations

Biological Activity for PF 04620110

PF 04620110 is a potent and selective DGAT-1 inhibitor (IC₅₀ = 19 nM). Exhibits >1000-fold selectivity for DGAT-1 over DGAT-2, and no significant activity against a range of other enzymes, ion channels and receptors. Reduces plasma triglyceride levels in a rat lipid challenge model. Orally bioavailable.

Licensing Information

Sold for research purposes under agreement from Pfizer Inc.

Compound Libraries for PF 04620110

PF 04620110 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for PF 04620110

M. Wt	396.44
Formula	C₂₁H₂₄N₄O₄
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	1109276-89-2
PubChem ID	46926360
InChi Key	GEVVQZHMFVFGLN-UHFFFAOYSA-N
Smiles	O=C1N(C2=CC=C([C@@H]3CC[C@@H](CC(O)=O)CC3)C=C2)CCOC4=NC=NC(N)=C41

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for PF 04620110

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	7.93	20

Preparing Stock Solutions for PF 04620110

The following data is based on the product molecular weight 396.44.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.2 mM	12.61 mL	63.06 mL	126.12 mL
1 mM	2.52 mL	12.61 mL	25.22 mL
2 mM	1.26 mL	6.31 mL	12.61 mL
10 mM	0.25 mL	1.26 mL	2.52 mL

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References for PF 04620110

References are publications that support the biological activity of the product.

Dow Discovery of PF-04620110, a potent, selective, and orally bioavailable inhibitor of DGAT-1. ACS Med.Chem.Lett. 2011 PMID: 24900321