PF 04457845

Name: PF 04457845
Brand: Tocris Bioscience
SKU: 6374

Tocris Bioscience, part of Bio-Techne | Catalog # 6374

Citations (4)

COA / SDS

Potent and selective irreversible FAAH inhibitor

Key Product Details

Description:	Potent and selective irreversible FAAH inhibitor
Chemical Name:	N-3-Pyridazinyl-4-[[3-[[5-(trifluoromethyl)-2-pyridinyl]oxy]phenyl]methylene]-1-piperidinecarboxamide
Purity:	≥98% (HPLC)
Molecular Weight:	455.43

View Full Technical Details for PF 04457845

Technical Data
Citations

Biological Activity for PF 04457845

PF 04457845 is a potent and selective irreversible FAAH inhibitor (IC₅₀ = 7.2 nM, which is selective for FAAH over a panel of other serine hydrolases. PF 04457845 exhibits efficacy in a rat inflammatory pain model, and is orally bioavailable and brain penetrant.

Licensing Information

Sold for research purposes under agreement from Pfizer Inc

Compound Libraries for PF 04457845

PF 04457845 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

External Portal Information

Chemicalprobes.org and the Chemical Probes webpages of the Structural Genomics Consortium are portals that offer independent guidance on the selection and/or application of small molecules for research. The use of PF 04457845 is reviewed on chemicalprobes.org and the SGC website.

Technical Data for PF 04457845

M. Wt	455.43
Formula	C₂₃H₂₀F₃N₅O₂
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	1020315-31-4
PubChem ID	24771824
InChi Key	BATCTBJIJJEPHM-UHFFFAOYSA-N
Smiles	FC(F)(C1=CC=C(N=C1)OC2=CC=CC(/C=C3CCN(C(NC4=CC=CN=N4)=O)CC\3)=C2)F

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for PF 04457845

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	45.54	100
	ethanol	9.11	20

Preparing Stock Solutions for PF 04457845

The following data is based on the product molecular weight 455.43.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.20 mL	10.98 mL	21.96 mL
5 mM	0.44 mL	2.20 mL	4.39 mL
10 mM	0.22 mL	1.10 mL	2.20 mL
50 mM	0.04 mL	0.22 mL	0.44 mL

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References for PF 04457845

References are publications that support the biological activity of the product.

Johnson Discovery of PF-04457845: a highly potent, orally bioavailable, and selective urea FAAH inhibitor. ACS Med.Chem.Lett. 2011 PMID: 21666860
Ahn Mechanistic and pharmacological characterization of PF-04457845: a highly potent and selective fatty acid amide hydrolase inhibitor that reduces inflammatory and noninflammatory pain. J.Pharmacol.Exp.Ther. 2011 PMID: 21505060