PF 04457845
Tocris Bioscience, part of Bio-Techne | Catalog # 6374
Potent and selective irreversible FAAH inhibitor
Key Product Details
Description
Potent and selective irreversible FAAH inhibitor
Product Description
PF 04457845 is a potent and selective irreversible FAAH inhibitor (IC50 = 7.2 nM, which is selective for FAAH over a panel of other serine hydrolases. PF 04457845 exhibits efficacy in a rat inflammatory pain model, and is orally bioavailable and brain penetrant.Licensing Information
Sold for research purposes under agreement from Pfizer IncExternal Portal Information
Chemicalprobes.org and the Chemical Probes webpages of the Structural Genomics Consortium are portals that offer independent guidance on the selection and/or application of small molecules for research. The use of PF 04457845 is reviewed on chemicalprobes.org and the SGC website.Product Specifications
Molecular Weight
455.43
Formula
C23H20F3N5O2
Storage
Store at +4°C
Purity
≥98% (HPLC)
Chemical Name
N-3-Pyridazinyl-4-[[3-[[5-(trifluoromethyl)-2-pyridinyl]oxy]phenyl]methylene]-1-piperidinecarboxamide
CAS Number
1020315-31-4
PubChem ID
24771824
InChI Key
BATCTBJIJJEPHM-UHFFFAOYSA-N
SMILES
FC(F)(C1=CC=C(N=C1)OC2=CC=CC(/C=C3CCN(C(NC4=CC=CN=N4)=O)CC\3)=C2)F
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 45.54 | 100 | |
| Ethanol | 9.11 | 20 |
Preparing Stock Solutions
for PF 04457845
The following data is based on the product molecular weight 455.43
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.20 mL | 10.98 mL | 21.96 mL |
| 5 mM | 0.44 mL | 2.20 mL | 4.39 mL |
| 10 mM | 0.22 mL | 1.10 mL | 2.20 mL |
| 50 mM | 0.04 mL | 0.22 mL | 0.44 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Johnson Discovery of PF-04457845: a highly potent, orally bioavailable, and selective urea FAAH inhibitor. ACS Med.Chem.Lett. 2011 PMID: 21666860
- Ahn Mechanistic and pharmacological characterization of PF-04457845: a highly potent and selective fatty acid amide hydrolase inhibitor that reduces inflammatory and noninflammatory pain. J.Pharmacol.Exp.Ther. 2011 PMID: 21505060
Product Specific Notices for PF 04457845
For research use only
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