PF 04449913 maleate

Tocris Bioscience, part of Bio-Techne | Catalog # 6538

Potent Smo antagonist
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Key Product Details

Description

Potent Smo antagonist

Alternative Names

glasdegib,PF-913

View all Smoothened Receptor Antagonists »

Product Description

PF 04449913 maleate is a potent Smo antagonist (IC50 = 5 nM). Attenuates the leukemia-initiation potential of AML cells in a serial transplantation mouse model. Also eliminates self-propagation capacity of AML cells.

Licensing Information

Sold for research purposes under agreement from Pfizer Inc.

Product Specifications

Molecular Weight

490.51

Formula

C21H22N6O.C4H4O4

Storage

Store at +4°C

Purity

≥98% (HPLC)

Chemical Name

1-((2R,4R)-2-(1H-Benzimidazol-2-yl)-1-methylpiperidin-4-yl)-3-(4-cyanophenyl)urea maleate salt

CAS Number

2030410-25-2

PubChem ID

122640033

InChI Key

VJCVKWFBWAVYOC-UIXXXISESA-N

SMILES

OC(/C=C\C(O)=O)=O.CN1CC[C@@H](NC(NC2=CC=C(C#N)C=C2)=O)C[C@@H]1C3=NC4=CC=CC=C4N3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 49.05 100

Preparing Stock Solutions for PF 04449913 maleate

The following data is based on the product molecular weight 490.51

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.04 mL 10.19 mL 20.39 mL
5 mM 0.41 mL 2.04 mL 4.08 mL
10 mM 0.20 mL 1.02 mL 2.04 mL
50 mM 0.04 mL 0.20 mL 0.41 mL

Calculators

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Background References

References are publications that support the biological activity of the product.

Product Documents for PF 04449913 maleate

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for PF 04449913 maleate

For research use only

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