pep2-SVKI

Name: pep2-SVKI
Brand: Tocris Bioscience
SKU: 1597

Tocris Bioscience, part of Bio-Techne | Catalog # 1597

Citations (5)

COA / SDS

Peptide inhibitor of GluA2 subunit binding to GRIP, ABP and PICK1; increases AMPA current amplitude

Discontinued Product

1597 has been discontinued. View all AMPA Receptor Inhibitors products.

Technical Data
Citations

Product Description
Product Specifications
Solubility
Calculators
Background References
Product Documents
Specific Notices

Key Product Details

Description

Peptide inhibitor of GluA2 subunit binding to GRIP, ABP and PICK1; increases AMPA current amplitude

View all AMPA Receptor Inhibitors »

Product Description

pep2-SVKI is an inhibitor peptide corresponding to last 10 amino acids of the C-terminus of the GluA2 AMPA receptor subunit. Disrupts binding of GluA2 (at the C-terminal PDZ site) with glutamate receptor interacting protein (GRIP), AMPA receptor binding protein (ABP) and protein interacting with C kinase (PICK1). Increases amplitude of AMPA receptor-mediated currents and blocks long-term depression (LTD).

Control Peptide also available.

Product Specifications

Molecular Weight

1284.47

Formula

C₆₀H₉₃N₁₃O₁₈

Storage

Desiccate at -20°C

CAS Number

328944-75-8

PubChem ID

90479807

InChI Key

YWTNLHXVGSIPEM-YDSVATBTSA-N

SMILES

[H]N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)NCC(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)CC)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Soluble to 1mg/ml in water

Calculators

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Background References

References are publications that support the biological activity of the product.

Li AMPA receptor-PDZ interactions in facilitation of spinal sensory synapses. Nat.Neurosci. 1999 PMID: 10526335
Daw PDZ proteins interacting with C-terminal GluR2/3 are involved in a PKC-dependent regulation of AMPA receptors at hippocampal synapses. Neuron 2000 PMID: 11163273
Kim Interaction of the AMPA receptor subunit GluR2/3 with PDZ domains regulates hippocampal long-term depression. Proc.Natl.Acad.Sci.U.S.A. 2001 PMID: 11573007
Collingridge and Isaac Functional roles of protein interactions with AMPA and kainate receptors. Neurosci.Res. 2003 PMID: 12941441