PE 22-28

Name: PE 22-28
Brand: Tocris Bioscience
SKU: 7868

Tocris Bioscience, part of Bio-Techne | Catalog # 7868

COA / SDS

Potent inhibitor of TREK-1 channels

Key Product Details

Description:	Potent inhibitor of TREK-1 channels
Purity:	≥95% (HPLC)
Molecular Weight:	773.89

View Full Technical Details for PE 22-28

Technical Data
Citations

Biological Activity for PE 22-28

PE 22-28 is a potent inhibitor of potassium channel subfamily K member 2/TREK-1 (IC₅₀ = 0.12 nM). In rodent models of ischemia PE 22-28 reduces apoptotic death of β cells, increases hippocampal neurogenesis, and reduces stroke-induced motor and cognitive defects.

Technical Data for PE 22-28

M. Wt	773.89
Formula	C₃₅H₅₅N₁₁O₉
Single Letter Sequence	GVSWGLR
Storage	Store at -20°C
Purity	≥95% (HPLC)
CAS Number	1801959-12-5
PubChem ID	165437303
InChi Key	CMNBQRXBBJQIOA-YIHYGEMESA-N
Smiles	O=C(N[C@@H](C(C)C)C(N[C@@H](CO)C(N[C@@H](CC1=CNC2=CC=CC=C12)C(NCC(N[C@@H](CC(C)C)C(N[C@@H](CCCNC(N)=N)C(O)=O)=O)=O)=O)=O)=O)CN

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for PE 22-28

Solubility

Soluble to 2mg/ml in water

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References for PE 22-28

References are publications that support the biological activity of the product.

Pietri First evidence of protective effects on stroke recovery and post-stroke depression induced by sortilin-derived peptides. Neuropharmacology 2019 PMID: 31325429
Daziano Sortilin-derived peptides promote pancreatic beta-cell survival through CREB signaling pathway. Pharmacol.Res. 2021 PMID: 33737242