PDD 00017273
Tocris Bioscience, part of Bio-Techne | Catalog # 5952
Potent and selective PARG inhibitor; cell permeable
Key Product Details
Description
Potent and selective PARG inhibitor; cell permeable
Product Description
PDD 00017273 is a potent and selective poly (ADP ribose) glycohydrolase (PARG) inhibitor (IC50 = 26 nM). Exhibits >350-fold selectivity for PARG over a panel of ion channels, enzymes and receptors, including PARP1 and ARH3. Maintains PAR chains and induces DNA double-stranded breaks in cells following DNA damage. Decreases colony formation of ZR-75-1 BRCA1 WT cells and inhibits cancer cell survival. Cell permeable.External Portal Information
Chemicalprobes.org is a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of PDD 00017273 is reviewed on the chemical probes website.Product Specifications
Molecular Weight
514.62
Formula
C23H26N6O4S2
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
1-[(1,3-Dimethyl-1H-pyrazol-5-yl)methyl]-1,2,3,4-tetrahydro-N-(1-methylcyclopropyl)-3-[(2-methyl-5-thiazolyl)methyl]-2,4-dioxo-6-quinazolinesulfonamide
CAS Number
1945950-21-9
PubChem ID
121398766
InChI Key
IFWUBRBMMNTBRZ-UHFFFAOYSA-N
SMILES
O=C(C1=CC(S(NC2(CC2)C)(=O)=O)=CC=C1N3CC4=CC(C)=NN4C)N(CC5=CN=C(C)S5)C3=O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 51.46 | 100 |
Preparing Stock Solutions
for PDD 00017273
The following data is based on the product molecular weight 514.62
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.94 mL | 9.72 mL | 19.43 mL |
| 5 mM | 0.39 mL | 1.94 mL | 3.89 mL |
| 10 mM | 0.19 mL | 0.97 mL | 1.94 mL |
| 50 mM | 0.04 mL | 0.19 mL | 0.39 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Houl Selective small molecule PARG inhibitor causes replication fork stalling and cancer cell death. Nat.Commun. 2019 PMID: 31827085
- Kliza Reading ADP-ribosylation signaling using chemical biology and interaction proteomics. Mol. Cell 2021 PMID: 34551281
- Gravells Specific killing of DNA damage-response deficient cells with inhibitor of poly(ADP-ribose) glycohydrolase. DNA Repair 2017 PMID: 28254358
Product Specific Notices for PDD 00017273
For research use only
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