PDD 00017238
Tocris Bioscience, part of Bio-Techne | Catalog # 7007
High affinity and potent PARG inhibitor
Product Description
PDD 00017238 is a high affinity and potent PARG inhibitor (Kd = 3.09 nM; IC50 = 40 nM).Negative control PDD 00031705 (Cat. No. 7009) also available.
Licensing Information
Sold under license from Cancer Research Technology Ltd (Ximbio).Product Specifications
Molecular Weight
476.59
Formula
C19H20N6O3S3
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
1-[(2,4-Dimethyl-5-thiazolyl)methyl]-2,3-dihydro-N-(1-methylcyclopropyl)-2-oxo-3-(1,2,4-thiadiazol-5-yl)-1H-benzimidazole-5-sulfonamide
CAS Number
1952247-05-0
PubChem ID
121415983
InChI Key
FLUZEVGWXJVSPX-UHFFFAOYSA-N
SMILES
CC1=NC(C)=C(S1)CN2C(N(C3=CC(S(=O)(NC4(CC4)C)=O)=CC=C23)C5=NC=NS5)=O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 0.95 | 2 |
Preparing Stock Solutions
for PDD 00017238
The following data is based on the product molecular weight 476.59
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.02 mM | 104.91 mL | 524.56 mL | 1,049.12 mL |
| 0.1 mM | 20.98 mL | 104.91 mL | 209.82 mL |
| 0.2 mM | 10.49 mL | 52.46 mL | 104.91 mL |
| 1 mM | 2.10 mL | 10.49 mL | 20.98 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- James First-in-class chemical probes against poly(ADP-ribose) glycohydrolase (PARG) inhibit DNA repair with differential pharmacology to Olaparib. ACS Chem.Biol. 2016 PMID: 27689388
Product Specific Notices for PDD 00017238
For research use only
Loading...
Loading...