PD 81723

Product Description

PD 81723 is an allosteric potentiator at the adenosine A₁ receptor; acts via agonist-dependent and -independent mechanisms. Enhances agonist affinity for, and increased t_½ of dissociation from, the receptor. Also inhibits basal and forskolin-stimulated adenylyl cyclase (AC) activity in A₁ receptors expressed in CHO cells, possibly via direct potentiation of constitutive receptor activity or by direct inhibition of AC. Active in vivo.

Solubility

Preparing Stock Solutions for PD 81723

The following data is based on the product molecular weight 299.31

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.34 mL	16.71 mL	33.41 mL
5 mM	0.67 mL	3.34 mL	6.68 mL
10 mM	0.33 mL	1.67 mL	3.34 mL
50 mM	0.07 mL	0.33 mL	0.67 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Musser Adenosine A₁ receptor-dependent and -independent effects of the allosteric enhancer PD 81,723. J.Pharmacol.Exp.Ther. 1999 PMID: 9918544
• Kollias-Baker Agonist-independent effect of an allosteric enhancer of the A₁ adenosine receptor in CHO cells stably expressing the recombinant human A₁ receptor. J.Pharmacol.Exp.Ther. 1997 PMID: 9152383
• Mizumura PD 81,723, an allosteric enhancer of the A₁ adenosine receptor, lowers the threshold for ischemic preconditioning in dogs. Circ.Res. 1996 PMID: 8781475
• Bruns Structure-activity relationships for enhancement of adenosine A₁ receptor binding by 2-amino-3-benzoylthiophenes. Mol.Pharmacol. 1990 PMID: 2250667