PD 4'-piperazine

Name: PD 4'-piperazine
Brand: Tocris Bioscience
SKU: 7859

Tocris Bioscience, part of Bio-Techne | Catalog # 7859

COA / SDS

Stable cereblon ligand, for PROTAC synthesis

Key Product Details

Description:	Stable cereblon ligand, for PROTAC synthesis
Chemical Name:	Dihydro-1-[4-(1-piperazinyl)phenyl]-2,4(1H,3H)-pyrimidinedione dihydrochloride
Purity:	≥95% (HPLC)
Molecular Weight:	347.24

View Full Technical Details for PD 4'-piperazine

Technical Data
Citations

Biological Activity for PD 4'-piperazine

PD 4'-piperazine is a cereblon ligand that can be used for PROTAC^® Degrader development. The compound can be used to develop PD-PROTAC molecules that exhibit improved stability and potency compared with PROTACs synthesized using IMiD (immunomodulatory imide drug) analogs.

Please contact us for SD files of our available Degrader Building Blocks.

PROTAC^® is a registered trademark of Arvinas Operations, Inc., and is used under license.

Usage Guidelines

This product is provided for use in onward chemistry. Suitable solvents can be used.

Technical Data for PD 4'-piperazine

M. Wt	347.24
Formula	C₁₄H₁₈N₄O₂.2HCl
Storage	Store at -20°C
Purity	≥95% (HPLC)
CAS Number	3054083-78-9
PubChem ID	154941993
InChi Key	ZHZKTFGEZSNJNW-UHFFFAOYSA-N
Smiles	O=C1NC(CCN1C2=CC=C(N3CCNCC3)C=C2)=O.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for PD 4'-piperazine

References are publications that support the biological activity of the product.

Jarusiewicz Phenyl dihydrouracil: an alternative cereblon binder for PROTAC design. ACS Med.Chem.Lett.