PD 4'-piperazine

Tocris Bioscience, part of Bio-Techne | Catalog # 7859

Stable cereblon ligand, for PROTAC synthesis
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Key Product Details

Description

Stable cereblon ligand, for PROTAC synthesis

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Product Description

PD 4'-piperazine is a cereblon ligand that can be used for PROTAC® Degrader development. The compound can be used to develop PD-PROTAC molecules that exhibit improved stability and potency compared with PROTACs synthesized using IMiD (immunomodulatory imide drug) analogs.

Please contact us for SD files of our available Degrader Building Blocks.

PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.

Usage Guidelines

This product is provided for use in onward chemistry. Suitable solvents can be used.

Product Specifications

Molecular Weight

347.24

Formula

C14H18N4O2.2HCl

Storage

Store at -20°C

Purity

≥95% (HPLC)

Chemical Name

Dihydro-1-[4-(1-piperazinyl)phenyl]-2,4(1H,3H)-pyrimidinedione dihydrochloride

CAS Number

3054083-78-9

PubChem ID

154941993

InChI Key

ZHZKTFGEZSNJNW-UHFFFAOYSA-N

SMILES

O=C1NC(CCN1C2=CC=C(N3CCNCC3)C=C2)=O.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Calculators

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Reconstitution Calculator

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Background References

References are publications that support the biological activity of the product.

  • Jarusiewicz Phenyl dihydrouracil: an alternative cereblon binder for PROTAC design. ACS Med.Chem.Lett.

Product Documents for PD 4'-piperazine

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for PD 4'-piperazine

For research use only

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