PD 184352 is a selective MEK inhibitor (K_i = 300 nM in vitro). Suppresses FGF-mediated angiogenesis in vivo and decreases VEGF expression. Enhances the therapeutic efficacy of taxol (Cat. No. 1097) in vivo. Orally active.

Licensing Information

Sold for research purposes under agreement from Pfizer Inc.

Product Specifications

Molecular Weight

478.66

Formula

C₁₇H₁₄ClF₂IN₂O₂

Storage

Store at +4°C

Purity

≥98% (HPLC)

Chemical Name

2-[(2-Chloro-4-iodophenyl)amino]-N-cyclopropylmethoxy)-3,4-difluorobenzamide

CAS Number

212631-79-3

PubChem ID

6918454

InChI Key

GFMMXOIFOQCCGU-UHFFFAOYSA-N

SMILES

FC1=C(NC2=CC=C(I)C=C2Cl)C(C(NOCC3CC3)=O)=CC=C1F

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	47.87	100
	Ethanol	11.97	25

Preparing Stock Solutions for PD 184352

The following data is based on the product molecular weight 478.66

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.09 mL	10.45 mL	20.89 mL
5 mM	0.42 mL	2.09 mL	4.18 mL
10 mM	0.21 mL	1.04 mL	2.09 mL
50 mM	0.04 mL	0.21 mL	0.42 mL

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Background References

References are publications that support the biological activity of the product.

McDaid Enhancement of the therapeutic efficacy of Tax. by the mitogen-activated protein kinase kinase inhibitor CI-1040 in nude mice bearing human heterotransplants. Cancer Res. 2005 PMID: 15805287
Solit BRAF mutation predicts sensitivity to MEK inhibition. Nature 2006 PMID: 16273091
Allen CI-1040 (PD184252), a targeted signal transduction inhibitor of MEK (MAPKK). Semin.Oncol. 2003 PMID: 14613031

PD 184352

Tocris Bioscience, part of Bio-Techne | Catalog # 4237

Key Product Details

Description

Alternative Names

View all MEK Inhibitors »

Product Description