PD 184352

Name: PD 184352
Brand: Tocris Bioscience
SKU: 4237
Rating: 5 (1 reviews)

Tocris Bioscience a Bio-Techne Brand

Catalog # 4237

Citations (3)

(1)

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Key Product Details

Description:	Selective MEK inhibitor
Alternative Names:	CI-1040
Chemical Name:	2-[(2-Chloro-4-iodophenyl)amino]-N-cyclopropylmethoxy)-3,4-difluorobenzamide
Molecular Weight:	478.66

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Biological Activity for PD 184352

PD 184352 is a selective MEK inhibitor (K_i = 300 nM in vitro). Suppresses FGF-mediated angiogenesis in vivo and decreases VEGF expression. Enhances the therapeutic efficacy of taxol (Cat. No. 1097) in vivo. Orally active.

Licensing Information

Sold for research purposes under agreement from Pfizer Inc.

Technical Data for PD 184352

M. Wt	478.66
Formula	C₁₇H₁₄ClF₂IN₂O₂
Storage	Store at +4°C
CAS Number	212631-79-3
PubChem ID	6918454
InChi Key	GFMMXOIFOQCCGU-UHFFFAOYSA-N
Smiles	FC1=C(NC2=CC=C(I)C=C2Cl)C(C(NOCC3CC3)=O)=CC=C1F

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for PD 184352

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	47.87	100
	ethanol	11.97	25

Preparing Stock Solutions for PD 184352

The following data is based on the product molecular weight 478.66.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.09 mL	10.45 mL	20.89 mL
5 mM	0.42 mL	2.09 mL	4.18 mL
10 mM	0.21 mL	1.04 mL	2.09 mL
50 mM	0.04 mL	0.21 mL	0.42 mL

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References for PD 184352

References are publications that support the biological activity of the product.

Solit BRAF mutation predicts sensitivity to MEK inhibition. Nature 2006 PMID: 16273091
McDaid Enhancement of the therapeutic efficacy of Tax. by the mitogen-activated protein kinase kinase inhibitor CI-1040 in nude mice bearing human heterotransplants. Cancer Res. 2005 PMID: 15805287
Allen CI-1040 (PD184252), a targeted signal transduction inhibitor of MEK (MAPKK). Semin.Oncol. 2003 PMID: 14613031

Citations for PD 184352 (3)

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Citations are publications that use Bio-Techne products. Selected citations for PD 184352 include:

Wang et al. (2015) Activation of protein synthesis in mouse uterine epithelial cells by OE-17β is mediated by a PKC-ERK1/2-mTOR signaling pathway. BMC Res Notes. 112:E1382
PMID: 25733860
Wouters et al. (2014) Central role for protein kinase C in oxyt. and epidermal growth factor stimulated cyclooxygenase 2 expression in human myometrial cells. Genes Cancer. 7:357
PMID: 24916153
Martin et al. (2014) miR-155 induced transcriptome changes in the MCF-7 breast cancer cell line leads to enhanced mitogen activated protein kinase signaling. J Exp Bot. 5:353
PMID: 25352952

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The role of ERK pathway in LPA induced pro-inflammatory phenotype in microglia cells

Name: Joanna Plastira

Species: Mouse

Assay Type: In Vitro

Cell Line/Tissue: Primary murine microglia cells

The role of MAPK pathways (JNK, p38 and ERK) was studied in the LPA induced pro-inflammatory phenotype in microglia. In this case cells were incubated for the indicated time points with LPA (1µM) in the presence or absence of PD98059 (10µM) or PD184352 (10µM). A series of assays were performed. The effect of PD1843452 was more prominent in slightly inhibiting the expression of pp65.

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