PD 168077 maleate

Name: PD 168077 maleate
Brand: Tocris Bioscience
SKU: 1065

Tocris Bioscience, part of Bio-Techne | Catalog # 1065

Citations (8)

COA / SDS

High affinity, selective D4 agonist

Key Product Details

Description:	High affinity, selective D₄ agonist
Chemical Name:	N-[[4-(2-Cyanophenyl)-1-piperazinyl]methyl]-3-methylbenzamide maleate
Purity:	≥98% (HPLC)
Molecular Weight:	450.49

View Full Technical Details for PD 168077 maleate

Technical Data
Citations

Biological Activity for PD 168077 maleate

PD 168077 maleate is a potent D₄ dopamine receptor agonist (K_i = 8.7 nM) with > 400-fold selectivity over D₂ and > 300-fold selectivity versus D₃ subtypes respectively. Induces synaptic translocation of CaMK II to postsynaptic sites in cultured prefrontal cortical neurons. Centrally active in vivo.

Technical Data for PD 168077 maleate

M. Wt	450.49
Formula	C₂₀H₂₂N₄O.C₄H₄O₄
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	630117-19-0
PubChem ID	11957665
InChi Key	NAEUGRPISCANHO-BTJKTKAUSA-N
Smiles	OC(=O)\C=C/C(O)=O.CC1=CC(=CC=C1)C(=O)NCN1CCN(CC1)C1=C(C=CC=C1)C#N

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for PD 168077 maleate

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	45.05	100

Preparing Stock Solutions for PD 168077 maleate

The following data is based on the product molecular weight 450.49.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.22 mL	11.10 mL	22.20 mL
5 mM	0.44 mL	2.22 mL	4.44 mL
10 mM	0.22 mL	1.11 mL	2.22 mL
50 mM	0.04 mL	0.22 mL	0.44 mL

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References for PD 168077 maleate

References are publications that support the biological activity of the product.

Glase Substituted [(4-phenylpiperazinyl)methyl]benzamides: selective DA D₄ agonists. J.Med.Chem. 1997 PMID: 9191952
Gu Activation of DA D₄ receptors induces synaptic translocation of Ca²⁺/calmodulin-dependent protein kinase II in cultured prefrontal cortical neurons. Mol.Pharmacol. 2006 PMID: 16365279
Clifford and Waddington Topographically based search for an "Ethogram" among a series of novel D₄ DA receptor agonists and antagonists. Neuropsychopharmacology 2000 PMID: 10731629