PD 166793

Name: PD 166793
Brand: Tocris Bioscience
SKU: 2520

Tocris Bioscience, part of Bio-Techne | Catalog # 2520

Citations (10)

COA / SDS

Broad spectrum MMP inhibitor

Key Product Details

Description:	Broad spectrum MMP inhibitor
Chemical Name:	N-[(4'-Bromo[1,1'-biphenyl]-4-yl)sulfonyl]-L-valine
Purity:	≥98% (HPLC)
Molecular Weight:	412.3

View Full Technical Details for PD 166793

Technical Data
Citations

Biological Activity for PD 166793

PD 166793 is a broad spectrum MMP inhibitor. Displays high affinity for MMP-2, -3 and -13 (IC₅₀ values are 4, 7 and 8 nM respectively) and exhibits > 750-fold selectivity over MMP-1, -7 and -9. Attenuates left ventricular remodelling and dysfunction in rat model of heart failure.

Compound Libraries for PD 166793

PD 166793 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for PD 166793

M. Wt	412.3
Formula	C₁₇H₁₈BrNO₄S
Storage	Desiccate at +4°C
Purity	≥98% (HPLC)
CAS Number	199850-67-4
PubChem ID	9887870
InChi Key	GJOCABIDMCKCEG-INIZCTEOSA-N
Smiles	BrC1=CC=C(C2=CC=C(S(N[C@@H]([C@H](C)C)C(O)=O)(=O)=O)C=C2)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for PD 166793

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	41.23	100
	ethanol	41.23	100

Preparing Stock Solutions for PD 166793

The following data is based on the product molecular weight 412.3.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.43 mL	12.13 mL	24.25 mL
5 mM	0.49 mL	2.43 mL	4.85 mL
10 mM	0.24 mL	1.21 mL	2.43 mL
50 mM	0.05 mL	0.24 mL	0.49 mL

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References for PD 166793

References are publications that support the biological activity of the product.

Peterson Matrix metalloproteinase inhibition attenuates left ventricular remodeling and dysfunction in a rat model of progressive heart failure. Circulation 2001 PMID: 11342481
Chancey Effects of matrix metalloproteinase inhibition on ventricular remodeling due to volume overload. Circulation 2002 PMID: 11997287
O'Brien Structure-activity relationships and pharmacokinetic analysis for a series of potent, systemically available Biphenylsulfonamide matrix metalloproteinase inhibitors. J.Med.Chem. 2000 PMID: 10649971