PD 123319 ditrifluoroacetate
Tocris Bioscience, part of Bio-Techne | Catalog # 1361
Potent and selective non-peptide AT2 antagonist
Key Product Details
Description
Potent and selective non-peptide AT2 antagonist
Product Description
PD 123319 ditrifluoroacetate is a potent, selective, non-peptide angiotensin AT2 receptor antagonist. IC50 values are 34 and 210 nM in rat adrenal tissue and brain respectively.Product Specifications
Molecular Weight
736.67
Formula
C31H32N4O3.2CF3CO2H
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
(6S)1-[[4-(Dimethylamino)-3-methylphenyl]methyl]-5-(diphenylacetyl)-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine-6-carboxylic acid ditrifluoroacetate
CAS Number
136676-91-0
PubChem ID
6604951
InChI Key
GPKQIEZLHVGJQH-ZXVJYWQYSA-N
SMILES
O=C(C(C5=CC=CC=C5)C4=CC=CC=C4)N1[C@H]([C@](O)=O)CC(N(CC3=CC(C)=C(N(C)C)C=C3)C=N2)=C2C1.FC(F)(F)C(O)=O.FC(F)(F)C(O)=O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 51.06 | 100 |
Preparing Stock Solutions
for PD 123319 ditrifluoroacetate
The following data is based on the product molecular weight 736.67
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.36 mL | 6.79 mL | 13.57 mL |
| 5 mM | 0.27 mL | 1.36 mL | 2.71 mL |
| 10 mM | 0.14 mL | 0.68 mL | 1.36 mL |
| 50 mM | 0.03 mL | 0.14 mL | 0.27 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Boulay Modulation of angiotensin II binding affinity by allosteric interaction of polyvinyl sulfate with an intracellular domain of the DuP-753-sensitive angiotensin II receptor of bovine adrenal glomerulosa. Mol.Pharmacol. 1992 PMID: 1569928
- Tamura Induction of angiotensin II subtype 2 receptor-mediated blood pressure regulation in synthetic diet-fed rats. J.Hypertens. 2000 PMID: 10994755
- Blankley Synthesis and structure-activity relationships of a novel series of non-peptide angiotensin II receptor binding inhibitors specific for the AT2 subtype. J.Med.Chem. 1991 PMID: 1956044
Product Specific Notices for PD 123319 ditrifluoroacetate
For research use only
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