PD 102807
Tocris Bioscience, part of Bio-Techne | Catalog # 1671
Selective M4 antagonist
Product Description
PD 102807 is a selective M4 muscarinic receptor antagonist. IC50 values are 91, 6559, 3441, 950 and 7412 nM for human M4, M1, M2, M3, and M5 receptors respectively. Promotes self-renewal of erythroid progenitors.Product Specifications
Molecular Weight
392.45
Formula
C23H24N2O4
Storage
Store at RT
Purity
≥98% (HPLC)
Chemical Name
3,6a,11,14-Tetrahydro-9-methoxy-2-methyl-(12H)-isoquino[1,2-b]pyrrolo[3,2-f][1,3]benzoxazine-1-carboxylic acid, ethyl ester
CAS Number
23062-91-1
PubChem ID
4995951
InChI Key
VDDUJINYXKGZLV-UHFFFAOYSA-N
SMILES
CCOC(=O)C1=C(C)NC2=CC=C3OC4N(CCC5=CC(OC)=CC=C45)CC3=C12
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 39.24 | 100 |
Preparing Stock Solutions
for PD 102807
The following data is based on the product molecular weight 392.45
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.55 mL | 12.74 mL | 25.48 mL |
| 5 mM | 0.51 mL | 2.55 mL | 5.10 mL |
| 10 mM | 0.25 mL | 1.27 mL | 2.55 mL |
| 50 mM | 0.05 mL | 0.25 mL | 0.51 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Trivedi Muscarinic acetylcholine receptor regulates self-renewal of early erythroid progenitors. Sci.Transl.Med. 2019 PMID: 31554738
- Bohme Synthesis and pharmacology of benzoxazines as highly selective antagonists at M4 muscarinic receptors. J.Med.Chem. 2002 PMID: 12086495
- Kitaichi A novel muscarinic M4 receptor antagonist provides further evidence of an autoreceptor role for the muscarinic M2 receptor sub-type. Eur.J.Pharmacol. 1999 PMID: 10556681
- Augelli-Szafran Identification and characterization of m4 selective muscarinic antagonists. Bioorg.Med.Chem.Lett. 1998 PMID: 9873472
Product Specific Notices for PD 102807
For research use only
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