PAMP-12 (human, porcine)

Name: PAMP-12 (human, porcine)
Brand: Tocris Bioscience
SKU: 6551

Tocris Bioscience, part of Bio-Techne | Catalog # 6551

COA / SDS

Potent MRGPRX2 agonist

Key Product Details

Description:	Potent MRGPRX2 agonist
Purity:	≥95% (HPLC)
Molecular Weight:	1618.95

View Full Technical Details for PAMP-12 (human, porcine)

Technical Data
Citations

Biological Activity for PAMP-12 (human, porcine)

PAMP-12 (human, porcine) is a potent endogenous peptide agonist of Mas related GPR X2 (MRGPRX2, EC₅₀ = 57.2 nM). Corresponds to amino acids 9 to 20 of proadrenomedullin.

Technical Data for PAMP-12 (human, porcine)

M. Wt	1618.95
Formula	C₇₇H₁₁₉N₂₅O₁₄
Single Letter Sequence	FRKKWNKWALSR (Modification: Arg-12 = C-terminal amide)
Storage	Store at -20°C
Purity	≥95% (HPLC)
CAS Number	196305-05-2
PubChem ID	16137959
InChi Key	DNUWKYBPCFUDDK-DYQOJKGJSA-N
Smiles	[H]N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for PAMP-12 (human, porcine)

Solubility

Soluble to 1mg/ml in water

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References for PAMP-12 (human, porcine)

References are publications that support the biological activity of the product.

Lansu In silico design of novel probes for the atypical opioid receptor MRGPRX2. Nat.Chem.Biol. 2017 PMID: 28288109
Kamohara Identification of MrgX2 as a human G-protein-coupled receptor for proadrenomedullin N-terminal peptides. Biochem.Biophys.Res.Commun. 2005 PMID: 15823563