Pam2CSK4

Name: Pam2CSK4
Brand: Tocris Bioscience
SKU: 4637
Rating: 5 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 4637

(1)

Citations (15)

COA / SDS

TLR2/6 agonist; induces TNF-α production

Key Product Details

Description:	TLR2/6 agonist; induces TNF-α production
Purity:	≥95% (HPLC)
Molecular Weight:	1271.83

View Full Technical Details for Pam2CSK4

Technical Data
Citations / Reviews (1)

Biological Activity for Pam2CSK4

Pam2CSK4 is a toll-like receptor 2/6 (TLR2/6) agonist. Induces TNF-α production in human mononuclear cells. Also induces proliferation and activation of mouse splenic B cells.

Technical Data for Pam2CSK4

M. Wt	1271.83
Formula	C₆₅H₁₂₆N₁₀O₁₂S
Single Letter Sequence	CSKKKK (Modifications: Cys-1 = S-[2,3-Bis(palmitoyloxy)-(2-R)-propyl]-Cys)
Storage	Store at -20°C
Purity	≥95% (HPLC)
CAS Number	868247-72-7
PubChem ID	71457280
InChi Key	LJUIOEFZFQRWJG-GHYFRYPYSA-N
Smiles	[H]N[C@@H](CSC[C@@H](COC(=O)CCCCCCCCCCCCCCC)OC(=O)CCCCCCCCCCCCCCC)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Pam2CSK4

Solubility

Soluble to 1mg/ml in 0.25% acetic acid

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References for Pam2CSK4

References are publications that support the biological activity of the product.

Omueti Domain exchange between human Toll-like receptors 1 and 6 reveals a region required for lipopeptide discrimination. J.Biol.Chem. 2005 PMID: 16129684
Schromm Physiochemical and biological analysis of synthetic bacterial lipopeptides: validity of the concept of endotoxic conformation. J.Biol.Chem. 2007 PMID: 17308304
Boeglin Toll-like receptor agonists synergize with CD40L to induce either proliferation or plasma cell differentiation of mouse B cells. PLoS One 2011 PMID: 21991317