PACAP 6-38

Name: PACAP 6-38
Brand: Tocris Bioscience
SKU: 3236

Tocris Bioscience a Bio-Techne Brand

Catalog # 3236

Citations (1)

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Key Product Details

Description:	Potent PAC₁ receptor antagonist
Purity:	≥95% (HPLC)
Molecular Weight:	4024.78

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Biological Activity for PACAP 6-38

PACAP 6-38 is a potent and competitive pituitary adenylate cyclase-activating polypeptide receptor (PAC)₁ antagonist (IC₅₀ = 2 nM). Inhibits PACAP(1-27)-induced stimulation of adenylate cyclase (K_i = 1.5 nM). Antitumor activity in vivo.

Technical Data for PACAP 6-38

M. Wt	4024.78
Formula	C₁₈₂H₃₀₀N₅₆O₄₅S
Single Letter Sequence	FTDSYSRYRKQMAVKKYLAAVLGKRYKQRVKNK (Modifications: Lys-33 = C-terminal amide)
Storage	Store at -20°C
Purity	≥95% (HPLC)
CAS Number	143748-18-9
PubChem ID	24868185
InChi Key	BGZYREVJBMQLGS-ONKNJJKASA-N
Smiles	[H]N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCCN)C(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for PACAP 6-38

Solubility

Soluble to 2mg/ml in water

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References for PACAP 6-38

References are publications that support the biological activity of the product.

Kojro The neuropeptide PACAP promotes a-secretase pathway for processing Alzheimer amyloid precursor protein. FASEB J. 2006 PMID: 16401644
Leyton PACAP(6-38) inhibits growth of prostate cancer cells. Cancer Lett. 1998 PMID: 9566707
Robberecht Structural requirements for the occupancy of pituitary adenylate-cyclase-activating-peptide (PACAP) receptors and adenylate cyclase activation in human neuroblastoma NB-OK-1 cell membranes. Discovery of PACAP(6-38) as a potent antagonist. Eur.J.Biochem. 1992 PMID: 1321043

Citations for PACAP 6-38 (1)

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Citations are publications that use Bio-Techne products. Selected citations for PACAP 6-38 include:

Maugeri et al. (2016) PACAP and VIP Inhibit the Invasiveness of Glioblastoma Cells Exposed to Hypoxia through the Regulation of HIFs and EGFR Expression. Proc Natl Acad Sci U S A. 7:139
PMID: 27303300

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Product Documents for PACAP 6-38

COA

Certificate of Analysis

To download a Certificate of Analysis, please select a batch below.