PA 8
Tocris Bioscience, part of Bio-Techne | Catalog # 6657
PAC1 receptor antagonist
Product Description
PA 8 is a PAC1 receptor antagonist. Inhibits PACAP-induced CREB phosphorylation in PAC1, but not VPAC1 or VPAC2, expressing cells. Also inhibits PACAP-induced increases in cAMP levels in vitro (IC50 = 2 nM) and PACAP-induced aversive responses and mechanical allodynia following intrathecal injection in vivo.Product Specifications
Molecular Weight
342.35
Formula
C17H18N4O4
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
2-Amino-5,8-dihydro-5-[3-methoxy-4-(2-propen-1-yloxy)phenyl]pyrido[2,3-d]pyrimidine-4,7(3H,6H)-dione
CAS Number
878437-15-1
PubChem ID
6485327
InChI Key
DCSWTWUTSKSXOV-UHFFFAOYSA-N
SMILES
COC1=C(C=CC(C2CC(NC3=C2C(N=C(N3)N)=O)=O)=C1)OCC=C
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 17.12 | 50 |
Preparing Stock Solutions
for PA 8
The following data is based on the product molecular weight 342.35
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.5 mM | 5.84 mL | 29.21 mL | 58.42 mL |
| 2.5 mM | 1.17 mL | 5.84 mL | 11.68 mL |
| 5 mM | 0.58 mL | 2.92 mL | 5.84 mL |
| 25 mM | 0.12 mL | 0.58 mL | 1.17 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Takasaki In silico screening identified novel small-molecule antagonists of PAC1 receptor. J.Pharmacol.Exp.Ther. 2018 PMID: 29363578
Product Specific Notices for PA 8
For research use only
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