P-3FAX-Neu5Ac
Tocris Bioscience, part of Bio-Techne | Catalog # 5760
Sialic acid analog; sialyltransferase inhibitor
Key Product Details
Description
Sialic acid analog; sialyltransferase inhibitor
Product Description
P-3FAX-Neu5Ac is a cell-permeable sialic acid analog. Deacetylation occurs intracellularly giving rise to a sialyltransferase inhibitor. Abolishes expression of SLex expression on HL-60 cells and reduces E-selectin and P-selectin binding. Prevents metastasis formation in a mouse lung metastasis model.Product Specifications
Molecular Weight
551.47
Formula
C22H30FNO14
Storage
Store at -20°C
Purity
≥97% (HPLC)
Chemical Name
5-(Acetylamino)-3,5-dideoxy-3-fluoro-D-erythro-α-L-manno-2-nonulopyranosonic acid methyl ester 2,4,7,8,9-pentaacetate
CAS Number
117405-58-0
PubChem ID
72698605
InChI Key
COXHVKPJIOSDPS-RTEYEINBSA-N
SMILES
FC1C(OC(C)=O)C(NC(C)=O)C([C@H](OC(C)=O)[C@H](OC(C)=O)COC(C)=O)OC(C(OC)=O)1OC(C)=O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 55.15 | 100 | |
| Ethanol | 27.57 | 50 |
Preparing Stock Solutions
for P-3FAX-Neu5Ac
The following data is based on the product molecular weight 551.47
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.81 mL | 9.07 mL | 18.13 mL |
| 5 mM | 0.36 mL | 1.81 mL | 3.63 mL |
| 10 mM | 0.18 mL | 0.91 mL | 1.81 mL |
| 50 mM | 0.04 mL | 0.18 mL | 0.36 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Büll Targeted delivery of a sialic acid-blocking glycomimetic to cancer cells inhibits metastatic spread. ACS Nano. 2015 PMID: 25575241
- Rillahan Global metabolic inhibitors of sialyl- and fucosyltransferases remodel the glycome. Nat.Chem.Biol. 2012 PMID: 22683610
Product Specific Notices for P-3FAX-Neu5Ac
For research use only
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