Oxotremorine sesquifumarate

Name: Oxotremorine sesquifumarate
Brand: Tocris Bioscience
SKU: 0843

Catalog # 0843

Citations (3)

COA / SDS

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Key Product Details

Description:	Muscarinic agonist
Chemical Name:	1-[4-(1-Pyrrolidinyl)-2-butynyl]-2-pyrrolidinone sesquifumarate
Purity:	≥98% (HPLC)
Molecular Weight:	380.4

View Full Technical Details for Oxotremorine sesquifumarate

Biological Activity

Oxotremorine sesquifumarate is a muscarinic agonist.

Technical Data

M. Wt	380.4
Formula	C₁₂H₁₈N₂O.1.5C₄H₄O₄
Storage	Store at RT
Purity	≥98% (HPLC)
CAS Number	17360-35-9
PubChem ID	6436473
InChi Key	WLYYOFJEBGHKEC-VQYXCCSOSA-N
Smiles	OC(=O)\C=C\C(O)=O.OC(=O)\C=C\C(O)=O.OC(=O)\C=C\C(O)=O.O=C1CCCN1CC#CCN1CCCC1.O=C1CCCN1CC#CCN1CCCC1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	water	9.51	25
	DMSO	38.04	100

Preparing Stock Solutions

The following data is based on the product molecular weight 380.4.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.63 mL	13.14 mL	26.29 mL
5 mM	0.53 mL	2.63 mL	5.26 mL
10 mM	0.26 mL	1.31 mL	2.63 mL
50 mM	0.05 mL	0.26 mL	0.53 mL

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Reconstitution Calculator

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References

References are publications that support the biological activity of the product.

Moroi-Fetters Muscarinic receptor-mediated phosphoinositide hydrolysis in the rat retina. J.Pharmacol.Exp.Ther. 1988 PMID: 2841451
Fisher Differential stimulation in inositol phospholipid turnover in brain by analogs of oxotremorine. J.Neurochem. 1984 PMID: 6088696

Citations for Oxotremorine sesquifumarate (3)

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Citations are publications that use Bio-Techne products. Selected citations for Oxotremorine sesquifumarate include:

Bragança et al. (2016) Ion Fluxes through KCa2 (SK) and Cav1 (L-type) Channels Contribute to Chronoselectivity of Adenosine A1 Receptor-Mediated Actions in Spontaneously Beating Rat Atria. Front Pharmacol. 7:45
PMID: 27014060
Carneiro et al. (2014) Activation of P2Y6 receptors increases the voiding frequency in anaesthetized rats by releasing ATP from the bladder urothelium. Br J Pharmacol. 171:3404
PMID: 24697602
Deng et al. (2013) Label-free cell phenotypic assessment of the biased agonism and efficacy of agonists at the endogenous muscarinic M3 receptors. J Pharmacol Toxicol Methods. 68:323
PMID: 23933114

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