OTX 015

Tocris Bioscience, part of Bio-Techne | Catalog # 6181

BET bromodomain inhibitor; orally bioavailable
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Key Product Details

Description

BET bromodomain inhibitor; orally bioavailable

Alternative Names

Birabresib

View all Bromodomain Inhibitors »

Product Description

OTX 015 is a BET bromodomain inhibitor (IC50 values are in the range 92 - 112 nM). Inhibits proliferation and induces apoptosis of leukemia cell lines in vitro. Decreases BRD2, BRD4 and c-MYC protein expression. Orally bioavailable.

Product Specifications

Molecular Weight

491.99

Formula

C25H22ClN5O2S

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

(6S)-4-(4-Chlorophenyl)-N-(4-hydroxyphenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetamide

CAS Number

202590-98-5

PubChem ID

9936746

InChI Key

GNMUEVRJHCWKTO-FQEVSTJZSA-N

SMILES

CC1=C(C2=C(N3C(C)=NN=C3[C@@H](N=C2C4=CC=C(C=C4)Cl)CC(NC5=CC=C(C=C5)O)=O)S1)C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 49.2 100
Ethanol 9.84 20

Preparing Stock Solutions for OTX 015

The following data is based on the product molecular weight 491.99

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.03 mL 10.16 mL 20.33 mL
5 mM 0.41 mL 2.03 mL 4.07 mL
10 mM 0.20 mL 1.02 mL 2.03 mL
50 mM 0.04 mL 0.20 mL 0.41 mL

Calculators

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Background References

References are publications that support the biological activity of the product.

Product Documents for OTX 015

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for OTX 015

For research use only

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