Org 25543 hydrochloride
Tocris Bioscience, part of Bio-Techne | Catalog # 4782
Potent and selective GlyT2 inhibitor
Key Product Details
Description
Potent and selective GlyT2 inhibitor
Product Description
Org 25543 hydrochloride is a potent and selective glycine transporter type 2 (GlyT2) inhibitor (IC50 = 16 nM for hGlyT2). Displays no activity at GlyT1 or 56 other common biological targets (≥ 100 μM), in a glycine uptake assay in CHO cells. Ameliorates mechanical allodynia after partial sciatic nerve ligation injury in mice.Product Specifications
Molecular Weight
448.98
Formula
C24H32lN2O4.HCl
Storage
Desiccate at RT
Purity
≥98% (HPLC)
Chemical Name
N-[[1-(Dimethylamino)cyclopentyl]methyl]-3,5-dimethoxy-4-(phenylmethoxy)benzamide hydrochloride
CAS Number
495076-64-7
PubChem ID
10095215
InChI Key
NIPQJILJYQVZJR-UHFFFAOYSA-N
SMILES
O=C(NCC2(N(C)C)CCCC2)C1=CC(OC)=C(OCC3=CC=CC=C3)C(OC)=C1.Cl
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 8.98 | 20 | |
| DMSO | 44.9 | 100 |
Preparing Stock Solutions
for Org 25543 hydrochloride
The following data is based on the product molecular weight 448.98
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.23 mL | 11.14 mL | 22.27 mL |
| 5 mM | 0.45 mL | 2.23 mL | 4.45 mL |
| 10 mM | 0.22 mL | 1.11 mL | 2.23 mL |
| 50 mM | 0.04 mL | 0.22 mL | 0.45 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Morita Spinal antiallodynia action of glycine transporter inhibitors in neuropathic pain models in mice. J.Pharmacol.Exp.Ther. 2008 PMID: 18448867
- Caulfield The first potent and selective inhibitors of the glycine transporter type 2. J.Med.Chem. 2001 PMID: 11495577
Product Specific Notices for Org 25543 hydrochloride
For research use only
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