Org 24598

Name: Org 24598
Brand: Tocris Bioscience
SKU: 4447

Tocris Bioscience, part of Bio-Techne | Catalog # 4447

Citations (8)

COA / SDS

Potent and selective inhibitor of the glial glycine transporter GlyT1b; active in vivo

Key Product Details

Description:	Potent and selective inhibitor of the glial glycine transporter GlyT1b; active in vivo
Chemical Name:	N-Methyl-N-[(3R)-3-phenyl-3-[4-(trifluoromethyl)phenoxy]propyl]-glycine
Purity:	≥98% (HPLC)
Molecular Weight:	367.36

View Full Technical Details for Org 24598

Technical Data
Citations

Biological Activity for Org 24598

Org 24598 is a potent and selective inhibitor of the glial glycine transporter GlyT1b (IC₅₀ = 6.9 nM). Displays negligible activity at GlyT-2, adrenoreceptors, dopamine, 5HT receptors and noradrenaline, dopamine, 5HT and GABA transporters (pIC₅₀ < 4). Active in vivo.

Technical Data for Org 24598

M. Wt	367.36
Formula	C₁₉H₂₀F₃NO₃
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	372198-97-5
PubChem ID	5311285
InChi Key	KZWQAWBTWNPFPW-QGZVFWFLSA-N
Smiles	CN(CC(O)=O)CC[C@@H](OC2=CC=C(C(F)(F)F)C=C2)C1=CC=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Org 24598

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	36.74	100

Preparing Stock Solutions for Org 24598

The following data is based on the product molecular weight 367.36.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.72 mL	13.61 mL	27.22 mL
5 mM	0.54 mL	2.72 mL	5.44 mL
10 mM	0.27 mL	1.36 mL	2.72 mL
50 mM	0.05 mL	0.27 mL	0.54 mL

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References for Org 24598

References are publications that support the biological activity of the product.

Brown Discovery and SAR of org 24598-a selective glycine uptake inhibitor. Bioorg.Med.Chem.Lett. 2001 PMID: 11454468
Williams Development of a scintillation proximity assay for analysis of Na⁺/Cl^- -dependent neurotransmitter transporter activity. Anal. Biochem. 2003 PMID: 12963052
Chue Glycine reuptake inhibition as a new therapeutic approach in schizophrenia: focus on the glycine transporter 1 (GlyT1). Curr.Pharm.Des. 2013 PMID: 23194655