Org 24598
Tocris Bioscience, part of Bio-Techne | Catalog # 4447
Potent and selective inhibitor of the glial glycine transporter GlyT1b; active in vivo
Key Product Details
Description
Potent and selective inhibitor of the glial glycine transporter GlyT1b; active in vivo
Product Description
Org 24598 is a potent and selective inhibitor of the glial glycine transporter GlyT1b (IC50 = 6.9 nM). Displays negligible activity at GlyT-2, adrenoreceptors, dopamine, 5HT receptors and noradrenaline, dopamine, 5HT and GABA transporters (pIC50 < 4). Active in vivo.Product Specifications
Molecular Weight
367.36
Formula
C19H20F3NO3
Storage
Store at +4°C
Purity
≥98% (HPLC)
Chemical Name
N-Methyl-N-[(3R)-3-phenyl-3-[4-(trifluoromethyl)phenoxy]propyl]-glycine
CAS Number
372198-97-5
PubChem ID
5311285
InChI Key
KZWQAWBTWNPFPW-QGZVFWFLSA-N
SMILES
CN(CC(O)=O)CC[C@@H](OC2=CC=C(C(F)(F)F)C=C2)C1=CC=CC=C1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 36.74 | 100 |
Preparing Stock Solutions
for Org 24598
The following data is based on the product molecular weight 367.36
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.72 mL | 13.61 mL | 27.22 mL |
| 5 mM | 0.54 mL | 2.72 mL | 5.44 mL |
| 10 mM | 0.27 mL | 1.36 mL | 2.72 mL |
| 50 mM | 0.05 mL | 0.27 mL | 0.54 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Brown Discovery and SAR of org 24598-a selective glycine uptake inhibitor. Bioorg.Med.Chem.Lett. 2001 PMID: 11454468
- Williams Development of a scintillation proximity assay for analysis of Na+/Cl- -dependent neurotransmitter transporter activity. Anal. Biochem. 2003 PMID: 12963052
- Chue Glycine reuptake inhibition as a new therapeutic approach in schizophrenia: focus on the glycine transporter 1 (GlyT1). Curr.Pharm.Des. 2013 PMID: 23194655
Product Specific Notices for Org 24598
For research use only
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