Orexin B (mouse)
Tocris Bioscience, part of Bio-Techne | Catalog # 1457
Endogenous agonist at OX1 and OX2
Key Product Details
Description
Endogenous agonist at OX1 and OX2
Product Description
Orexin B (mouse) is an endogenous agonist at orexin receptors. May be involved in the regulation of feeding, sleep-wake cycle and other hypothalamic functions. Orexin B exerts excitatory effects on nigral dopaminergic neurons and alleviates motor symptoms in a Parkinson's disease mouse model.Product Specifications
Molecular Weight
2936.43
Formula
C126H215N45O34S
Storage
Store at -20°C
Purity
≥95% (HPLC)
CAS Number
202801-92-1
PubChem ID
90479795
InChI Key
RLVZFBVFVIDDPQ-GWQFQBPDSA-N
SMILES
[H]N[C@@H](CCCNC(N)=N)C(=O)N1CCC[C@H]1C(=O)NCC(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(N)=O)C(=O)NCC(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCSC)C(N)=O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solubility | Soluble to 1mg/ml in water |
Calculators
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Background References
References are publications that support the biological activity of the product.
- Bian Orexin-B exerts excitatory effects on nigral dopaminergic neurons and alleviates motor disorders in MPTP parkinsonian mice. Neurosci.Lett. 2021 PMID: 34666119
- Sakurai Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behaviour. Cell 1998 PMID: 9491897
- Smart Orexins: a new family of neuropeptides. Br.J.Anaesth. 1999 PMID: 10690128
- Kilduff and Peyron The hypocretin/orexin ligand-receptor system: implications for sleep and sleep disorders. TiNS 2000 PMID: 10906799
Product Specific Notices for Orexin B (mouse)
For research use only
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