Orexin B (mouse) is an endogenous agonist at orexin receptors. May be involved in the regulation of feeding, sleep-wake cycle and other hypothalamic functions. Orexin B exerts excitatory effects on nigral dopaminergic neurons and alleviates motor symptoms in a Parkinson's disease mouse model.
This is the second Tocris peptide we have used in our study. The first one was from human origin (product #1456). Because a colleague suggested us to repeat the experiment with a peptide from mouse origin; we have chosen this product (Orexin B mouse). The results were amazing because the neuronal activation has increased at a level we were expecting to conduct the behavioural analysis. As shown in the attached graph, this compound stimulated neuronal activity at a hippocampus nuclei, as measured by immunoflurescence after compound delivery into the brain. We are very satisfied with the result and I recommed this Tocris product.
Which Brands are Currently Available on bio‑techne.com? R&D Systems, Tocris Bioscience and ProteinSimple branded products are available to purchase through bio‑techne.com. ProteinSimple branded instruments are available to quote. ACD branded products will be available on bio‑techne.com in the near future. Novus Biologicals branded products are not currently available on bio‑techne.com and can be found at novusbio.com.
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