Orexin B (human)

Name: Orexin B (human)
Brand: Tocris Bioscience
SKU: 1456
Rating: 5 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 1456

(1)

Citations (3)

COA / SDS

Endogenous agonist at OX1 and OX2

Key Product Details

Description:	Endogenous agonist at OX₁ and OX₂
Purity:	≥95% (HPLC)
Molecular Weight:	2899.36

View Full Technical Details for Orexin B (human)

Technical Data
Citations / Reviews (1)

Biological Activity for Orexin B (human)

Orexin B (human) is an endogenous agonist at orexin receptors (K_i values are 420 and 36 nM for OX₁ and OX₂ receptors, respectively). Stimulates feeding following central administration and may be involved in the control of sleep-wake cycle and other hypothalamic functions. Also neuroprotective for dopaminergic neurons in rat midbrain cultures.

Technical Data for Orexin B (human)

M. Wt	2899.36
Formula	C₁₂₃H₂₁₂N₄₄O₃₅S
Single Letter Sequence	RSGPPGLQGRLQRLLQASGNHAAGILTM (Modifications: Met-28 = C-terminal amide)
Storage	Store at -20°C
Purity	≥95% (HPLC)
CAS Number	205640-91-1
PubChem ID	90479794
InChi Key	DHBREICAXZPFDD-WMQZXSDYSA-N
Smiles	[H]N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CO)C(=O)NCC(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCSC)C(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Orexin B (human)

Solubility

Soluble to 1mg/ml in water

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

Mass

Concentration

Volume

M. Wt*

g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Concentration 1 (C1)

Volume 1 (V1)

Concentration 2 (C2)

Volume 2 (V2)

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

Volume (to add to vial)

Mass (in vial)

Desired Reconstitution Concentration

References for Orexin B (human)

References are publications that support the biological activity of the product.

Guerreiro The sleep-modulating peptide orexin-B protects midbrain DA neurons from degeneration, alone or in cooperation with nicotine. Mol.Pharmacol. 2015 PMID: 25552485
Sakurai Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behaviour. Cell 1998 PMID: 9491897
Smart Orexins: a new family of neuropeptides. Br.J.Anaesth. 1999 PMID: 10690128
Kilduff and Peyron The hypocretin/orexin ligand-receptor system: implications for sleep and sleep disorders. TiNS 2000 PMID: 10906799