OR-486

Name: OR-486
Brand: Tocris Bioscience
SKU: 0483

Tocris Bioscience a Bio-Techne Brand

Catalog # 0483

Citations (2)

COA / SDS

Catalog #

Availability

Size / Price

Qty

Key Product Details

Description:	COMT inhibitor
Chemical Name:	3,5-Dinitrocatechol
Purity:	≥99% (HPLC)
Molecular Weight:	200.11

View Full Technical Details for OR-486

Biological Activity for OR-486

OR-486 is a potent and selective inhibitor of catechol-O-methyl-transferase.

Technical Data for OR-486

M. Wt	200.11
Formula	C₆H₄N₂O₆
Storage	Store at RT
Purity	≥99% (HPLC)
CAS Number	7659-29-2
PubChem ID	3870203
InChi Key	VDCDWNDTNSWDFJ-UHFFFAOYSA-N
Smiles	OC1=CC(=CC(=C1O)[N+]([O-])=O)[N+]([O-])=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for OR-486

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	ethanol	20.01	100
	DMSO	20.01	100

Preparing Stock Solutions for OR-486

The following data is based on the product molecular weight 200.11.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	5.00 mL	24.99 mL	49.97 mL
5 mM	1.00 mL	5.00 mL	9.99 mL
10 mM	0.50 mL	2.50 mL	5.00 mL
50 mM	0.10 mL	0.50 mL	1.00 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

Mass

Concentration

Volume

M. Wt*

g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Concentration 1 (C1)

Volume 1 (V1)

Concentration 2 (C2)

Volume 2 (V2)

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

Volume (to add to vial)

Mass (in vial)

Desired Reconstitution Concentration

References for OR-486

References are publications that support the biological activity of the product.

Mannisto and Kaakola Rationale for selective COMT inhibitors as adjuncts in the drug treatment of Parkinson's disease. Pharmacol.Toxicol. 1990 PMID: 2196554
Borgulya Catechol-O-methyltransferase-inhibiting pyrocatechol derivatives: synthesis and structure-activity studies. Helv.Chim.Acta

Citations for OR-486 (2)

Showing 1 - 2 of 2 citations Showing All

Search Title:

Citations are publications that use Bio-Techne products. Selected citations for OR-486 include:

Ciszek et al. (2016) Persistent catechol-O-methyltransferase-dependent pain is initiated by peripheral β-andrenergic receptors. Anesthesiology. 124:1122
PMID: 26950706
Oróstica et al. (2014) OE increases cAMP in the oviductal secretory cells through a nongenomic mechanism. Reproduction. 148:285
PMID: 25038866

There are no citations that match your criteria.