OR-486

Name: OR-486
Brand: Tocris Bioscience
SKU: 0483

Catalog # 0483

Citations (2)

COA / SDS

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Key Product Details

Description:	COMT inhibitor
Chemical Name:	3,5-Dinitrocatechol
Purity:	≥99% (HPLC)
Molecular Weight:	200.11

View Full Technical Details for OR-486

Biological Activity

OR-486 is a potent and selective inhibitor of catechol-O-methyl-transferase.

Technical Data

M. Wt	200.11
Formula	C₆H₄N₂O₆
Storage	Store at RT
Purity	≥99% (HPLC)
CAS Number	7659-29-2
PubChem ID	3870203
InChi Key	VDCDWNDTNSWDFJ-UHFFFAOYSA-N
Smiles	OC1=CC(=CC(=C1O)[N+]([O-])=O)[N+]([O-])=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	ethanol	20.01	100
	DMSO	20.01	100

Preparing Stock Solutions

The following data is based on the product molecular weight 200.11.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	5.00 mL	24.99 mL	49.97 mL
5 mM	1.00 mL	5.00 mL	9.99 mL
10 mM	0.50 mL	2.50 mL	5.00 mL
50 mM	0.10 mL	0.50 mL	1.00 mL

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Reconstitution Calculator

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References

References are publications that support the biological activity of the product.

Mannisto and Kaakola Rationale for selective COMT inhibitors as adjuncts in the drug treatment of Parkinson's disease. Pharmacol.Toxicol. 1990 PMID: 2196554
Borgulya Catechol-O-methyltransferase-inhibiting pyrocatechol derivatives: synthesis and structure-activity studies. Helv.Chim.Acta

Citations for OR-486 (2)

Showing 1 - 2 of 2 citations Showing All

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Citations are publications that use Bio-Techne products. Selected citations for OR-486 include:

Ciszek et al. (2016) Persistent catechol-O-methyltransferase-dependent pain is initiated by peripheral β-andrenergic receptors. Anesthesiology. 124:1122
PMID: 26950706
Oróstica et al. (2014) OE increases cAMP in the oviductal secretory cells through a nongenomic mechanism. Reproduction. 148:285
PMID: 25038866

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