OR-486
Tocris Bioscience, part of Bio-Techne | Catalog # 0483
COMT inhibitor
Key Product Details
Description
COMT inhibitor
Product Description
OR-486 is a potent and selective inhibitor of catechol-O-methyl-transferase.Product Specifications
Molecular Weight
200.11
Formula
C6H4N2O6
Storage
Store at RT
Purity
≥99% (HPLC)
Chemical Name
3,5-Dinitrocatechol
CAS Number
7659-29-2
PubChem ID
3870203
InChI Key
VDCDWNDTNSWDFJ-UHFFFAOYSA-N
SMILES
OC1=CC(=CC(=C1O)[N+]([O-])=O)[N+]([O-])=O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 20.01 | 100 | |
| Ethanol | 20.01 | 100 |
Preparing Stock Solutions
for OR-486
The following data is based on the product molecular weight 200.11
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 5.00 mL | 24.99 mL | 49.97 mL |
| 5 mM | 1.00 mL | 5.00 mL | 9.99 mL |
| 10 mM | 0.50 mL | 2.50 mL | 5.00 mL |
| 50 mM | 0.10 mL | 0.50 mL | 1.00 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Borgulya Catechol-O-methyltransferase-inhibiting pyrocatechol derivatives: synthesis and structure-activity studies. Helv.Chim.Acta
- Mannisto and Kaakola Rationale for selective COMT inhibitors as adjuncts in the drug treatment of Parkinson's disease. Pharmacol.Toxicol. 1990 PMID: 2196554
Product Specific Notices for OR-486
For research use only
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