Opicapone

Name: Opicapone
Brand: Tocris Bioscience
SKU: 7668

Tocris Bioscience, part of Bio-Techne | Catalog # 7668

COA / SDS

COMT inhibitor

Key Product Details

Description:	COMT inhibitor
Chemical Name:	5-[3-(2,5-Dichloro-4,6-dimethyl-1-oxido-3-pyridinyl)-1,2,4-oxadiazol-5-yl]-3-nitro-1,2-benzenediol
Purity:	≥98% (HPLC)
Molecular Weight:	413.17

View Full Technical Details for Opicapone

Technical Data
Citations

Biological Activity for Opicapone

Opicapone is a reversible catechol O-methyltransferase inhibitor (COMT) inhibitor (IC₅₀ = 224 nM). Decreases the ATP content and mitochondrial membrane potential in cells (IC₅₀ values are 98 μM and 181 μM respectively). When administered with L-DOPA (Cat. No. 3788) it attenuates Parkinson's-like symptoms in an MPTP-induced animal model.

Technical Data for Opicapone

M. Wt	413.17
Formula	C₁₅H₁₀Cl₂N₄O₆
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	923287-50-7
PubChem ID	135565903
InChi Key	ASOADIZOVZTJSR-UHFFFAOYSA-N
Smiles	OC1=CC(C2=NC(C3=C(C(Cl)=C([N+]([O-])=C3Cl)C)C)=NO2)=CC([N+]([O-])=O)=C1O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Opicapone

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	41.32	100

Preparing Stock Solutions for Opicapone

The following data is based on the product molecular weight 413.17.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.42 mL	12.10 mL	24.20 mL
5 mM	0.48 mL	2.42 mL	4.84 mL
10 mM	0.24 mL	1.21 mL	2.42 mL
50 mM	0.05 mL	0.24 mL	0.48 mL

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References for Opicapone

References are publications that support the biological activity of the product.

Bonifácio Opicapone enhances the reversal of MPTP-induced Parkinson-like syndrome by levodopa in cynomolgus monkeys. Eur.J.Pharmacol. 2021 PMID: 33220276
Ettcheto The preclinical discovery and development of opicapone for the treatment of Parkinson's disease. Expert Opin.Drug Discov. 2020 PMID: 32450711