OPC 21268
Tocris Bioscience, part of Bio-Techne | Catalog # 3924
Orally active vasopressin V1 antagonist
Key Product Details
Description
Orally active vasopressin V1 antagonist
Product Description
OPC 21268 is a nonpeptide vasopressin V1 receptor antagonist. Displays greater affinity for rat V1 than human V1 (Ki values are 25 and 8800 nM respectively). Exhibits 1000-fold selectivity for V1 receptors over V2 receptors. Orally active.Product Specifications
Molecular Weight
449.54
Formula
C26H31N3O4
Storage
Store at +4°C
Purity
≥98% (HPLC)
Chemical Name
N-[3-[4-[[4-(3,4-Dihydro-2-oxo-1(2H)quinolinyl)-1-piperidinyl]carbonyl]phenoxy]propyl]-acetamide
CAS Number
131631-89-5
PubChem ID
114904
InChI Key
KSNUCNRMDYJBKT-UHFFFAOYSA-N
SMILES
O=C2N(C3CCN(C(C4=CC=C(OCCCNC(C)=O)C=C4)=O)CC3)C1=CC=CC=C1CC2
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 44.95 | 100 | |
| Ethanol | 11.24 | 25 |
Preparing Stock Solutions
for OPC 21268
The following data is based on the product molecular weight 449.54
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.22 mL | 11.12 mL | 22.24 mL |
| 5 mM | 0.44 mL | 2.22 mL | 4.45 mL |
| 10 mM | 0.22 mL | 1.11 mL | 2.22 mL |
| 50 mM | 0.04 mL | 0.22 mL | 0.44 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Imaizumi Effects of OPC-21268, an orally effective vasopressin V1 receptor antagonist in humans. Hypertension 1992 PMID: 1319959
- Thibonnier A molecular model of agonist and nonpeptide antagonist binding to the human V1 vascular vasopressin receptor. J.Pharmacol.Exp.Ther. 2000 PMID: 10871312
- Yamamura OPC-21268, an orally effective, nonpeptide vasopressin V1 receptor antagonist. Science 1991 PMID: 1850553
Product Specific Notices for OPC 21268
For research use only
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