ONO 8130
Tocris Bioscience, part of Bio-Techne | Catalog # 5406
EP1 receptor antagonist
Product Description
ONO 8130 is an EP1 receptor antagonist. Exhibits analgesic effect in a mouse model of cystitis. Orally bioavailable.Product Specifications
Molecular Weight
500.63
Formula
C25H28N2O5S2
Storage
Store at +4°C
Purity
≥98% (HPLC)
Chemical Name
4-[[[2,3-Dihydro-6-[(2-methylpropyl)[(4-methyl-2-thiazolyl)sulfonyl]amino]-1H-indene-5yl]oxy]methyl]benzoic acid
CAS Number
459841-96-4
PubChem ID
9827317
InChI Key
IOXMDBQCUCDLAF-UHFFFAOYSA-N
SMILES
CC(C)CN(S(C3=NC(C)=CS3)(=O)=O)C1=C(OCC4=CC=C(C(O)=O)C=C4)C=C(CCC2)C2=C1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 50.06 | 100 | |
| Ethanol | 10.01 | 20 |
Preparing Stock Solutions
for ONO 8130
The following data is based on the product molecular weight 500.63
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.00 mL | 9.99 mL | 19.97 mL |
| 5 mM | 0.40 mL | 2.00 mL | 3.99 mL |
| 10 mM | 0.20 mL | 1.00 mL | 2.00 mL |
| 50 mM | 0.04 mL | 0.20 mL | 0.40 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Lipina Modulators of the glycine site on NMDA receptors, D-serine and ALX 5407, display similar beneficial effects to cloz. in mouse models of schizophrenia. Psychopharmacology 2005 PMID: 15759151
- Miki ONO-8130, a selective prostanoid EP1 receptor antagonist, relieves bladder pain in mice with cyclophosphamide-induced cystitis. Pain 2011 PMID: 21396778
Product Specific Notices for ONO 8130
For research use only
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