ONO 6818
Tocris Bioscience, part of Bio-Techne | Catalog # 5651
High affinity and selective human neutrophil elastase 1 (HNE1) inhibitor; orally active
Key Product Details
Description
High affinity and selective human neutrophil elastase 1 (HNE1) inhibitor; orally active
Product Description
ONO 6818 is a high affinity and selective human neutrophil elastase 1 (HNE1) inhibitor (Ki = 12 nM). Exhibits >100-fold less activity at other related proteases including trypsin, pancreatic elastase, collagenase and murine macrophage elastase. Inhibits HNE-induced lung hemorrhaging and suppresses leukocyte levels in an in vivo model of COPD. Orally active.Product Specifications
Molecular Weight
452.51
Formula
C23H28N6O4
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
5-Amino-N-[1-[[5-(1,1-dimethylethyl)-1,3,4-oxadiazol-2-yl]carbonyl]-2-methylpropyl]-6-oxo-2-phenyl-1(6H)-pyrimidineacetamide
CAS Number
208848-19-5
PubChem ID
216294
InChI Key
YSIHYROEMJSOAS-UHFFFAOYSA-N
SMILES
O=C(NC(C(C)C)C(C1=NN=C(C(C)(C)C)O1)=O)CN(C(C2=CC=CC=C2)=NC=C3N)C3=O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 45.25 | 100 |
Preparing Stock Solutions
for ONO 6818
The following data is based on the product molecular weight 452.51
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.21 mL | 11.05 mL | 22.10 mL |
| 5 mM | 0.44 mL | 2.21 mL | 4.42 mL |
| 10 mM | 0.22 mL | 1.10 mL | 2.21 mL |
| 50 mM | 0.04 mL | 0.22 mL | 0.44 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Aoshiba Serine proteases increase oxidative stress in lung cells. Am.J.Physiol.Lung Cell Mol.Physiol. 2001 PMID: 11504681
- Stevens AZD9668: pharmacological characterization of a novel oral inhibitor of neutrophil elastase. J.Pharmacol.Exp.Ther. 2011 PMID: 21791628
- Hirota Effects of the neutrophil elastase inhibitor (ONO-6818) on acetic acid induced colitis in Syrian hamsters. J.Vet.Med.Sci. 2004 PMID: 15528853
Product Specific Notices for ONO 6818
For research use only
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