ONO 2506
Tocris Bioscience, part of Bio-Techne | Catalog # 4530
Inhibits S-100β synthesis; neuroprotective
Key Product Details
Description
Inhibits S-100β synthesis; neuroprotective
Alternative Names
Arundic acid
Product Description
ONO 2506 inhibits S-100β synthesis in activated cultured astrocytes. Prevents delayed infarct expansion 24 hours after permanent middle cerebral artery occlusion (pMCAO) in rats; also exhibits neuroprotective effects in mouse models of Parkinson's disease and Alzheimer's disease.Product Specifications
Molecular Weight
186.29
Formula
C11H22O2
Storage
Store at +4°C
Chemical Name
(2R)-2-Propyloctanoic acid
CAS Number
185517-21-9
PubChem ID
208925
InChI Key
YCYMCMYLORLIJX-SNVBAGLBSA-N
SMILES
CCC[C@H](CCCCCC)C(O)=O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 18.63 | 100 | |
| Ethanol | 18.63 | 100 |
Preparing Stock Solutions
for ONO 2506
The following data is based on the product molecular weight 186.29
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 5.37 mL | 26.84 mL | 53.68 mL |
| 5 mM | 1.07 mL | 5.37 mL | 10.74 mL |
| 10 mM | 0.54 mL | 2.68 mL | 5.37 mL |
| 50 mM | 0.11 mL | 0.54 mL | 1.07 mL |
Calculators
Molarity Calculator
Dilution Calculator
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Background References
References are publications that support the biological activity of the product.
- Tateishi Astrocytic activation and delayed infarct expansion after permanent focal ischemia in rats. Part II: suppression of astrocytic activation by a novel agent (R)-(-)-2-propyloctanoic acid (ONO-2506) leads to mitigation of delayed infarct expansion and early J.Cereb.Blood Flow Metab. 2002 PMID: 12045671
- Mori Arundic acid ameliorates cerebral amyloidosis and gliosis in Alzheimer transgenic mice. J.Pharmacol.Exp.Ther. 2006 PMID: 16709678
- Kato Arundic acid, an astrocyte-modulating agent, protects DArgic neurons against MPTP neurotoxicity in mice. Brain Res. 2004 PMID: 15567338
Product Specific Notices for ONO 2506
For research use only
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