Ondansetron hydrochloride

Name: Ondansetron hydrochloride
Brand: Tocris Bioscience
SKU: 2891

Tocris Bioscience, part of Bio-Techne | Catalog # 2891

Citations (20)

COA / SDS

Selective 5-HT3 antagonist

Key Product Details

Description:	Selective 5-HT₃ antagonist
Alternative Names:	GR 38032
Chemical Name:	1,2,3,9-Tetrahydro-9-methyl-3-[(2-methyl-1H-imidazol-1-yl)methyl]-4H-carbazol-4-one hydrochloride
Purity:	≥99% (HPLC)
Molecular Weight:	329.83

View Full Technical Details for Ondansetron hydrochloride

Technical Data
Citations

Biological Activity for Ondansetron hydrochloride

Ondansetron hydrochloride is a selective 5-HT₃ receptor antagonist (K_i= 6.16 nM). Also an inhibitor of human multidrug and toxin extrusion (MATE) transporter 1 (IC₅₀ = <10-160 nM). Ondansetron blocks 5-HT-evoked transient inward currents (IC₅₀= 0.1 nM) in human recombinant h5-HT_3A receptors. In an animal model of Parkinson's disease, Ondansetron reduces both the severity of dyskinesia and psychosis-like behaviors. Antiemetic; prevents emesis induced by cytotoxic drugs and radiation.

Technical Data for Ondansetron hydrochloride

M. Wt	329.83
Formula	C₁₈H₁₉N₃O.HCl
Storage	Store at RT
Purity	≥99% (HPLC)
CAS Number	99614-01-4
PubChem ID	68647
InChi Key	MKBLHFILKIKSQM-UHFFFAOYSA-N
Smiles	CN1C3=C(C=CC=C3)C2=C1CCC(CN4C(C)=NC=C4)C2=O.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Ondansetron hydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	water	16.49	50
	DMSO	32.98	100

Preparing Stock Solutions for Ondansetron hydrochloride

The following data is based on the product molecular weight 329.83.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.03 mL	15.16 mL	30.32 mL
5 mM	0.61 mL	3.03 mL	6.06 mL
10 mM	0.30 mL	1.52 mL	3.03 mL
50 mM	0.06 mL	0.30 mL	0.61 mL

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References for Ondansetron hydrochloride

References are publications that support the biological activity of the product.

Kwan Selective blockade of the 5-HT₃ receptor acutely alleviates dyskinesia and psychosis in the parkinsonian marmoset. Neuropharmacology 2021 PMID: 33152452
Brown Ion permeation and conduction in a human recombinant 5-HT3 receptor subunit (h5-HT3A). J.Physiol. 1998 PMID: 9508827
Wittwer Discovery of potent, selective multidrug and toxin extrusion transporter 1 (MATE1, SLC47A1) inhibitors through prescription drug profiling and computational modeling. J.Med.Chem. 2013 PMID: 23241029
Ginawi Ondansetron, a selective antagonist, antagonizes methamphetamine-induced anorexia in mice. Pharmacol.Res. 2005 PMID: 15661576
Ye Ondansetron: a selective 5-HT₃ receptor antagonist and its applications in CNS-related disorders. CNS Drug Rev. 2001 PMID: 11474424
Youssefyeh Development of high-affinity 5-HT₃ receptor antagonists. 1. Initial structure-activity relationship of novel benzamides. J.Med.Chem. 1992 PMID: 1312602