Olvanil

Name: Olvanil
Brand: tocris
SKU: 0934

Catalog # 0934

Citations (1)

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Key Product Details

Description:	Potent TRPV agonist
Alternative Names:	NE 19550
Chemical Name:	N-Vanillyloleoylamide
Purity:	≥98% (HPLC)
Molecular Weight:	417.63

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Biological Activity

Potent vanilloid receptor agonist (pEC₅₀ values are 8.1 and 7.7 at rat and human VR1 receptors respectively). Also blocks anandamide uptake (IC₅₀ = 9 μM) and may bind to CB₁ cannabinoid receptors. Antinociceptive following systemic administration.

Technical Data

M. Wt	417.63
Formula	C₂₆H₄₃NO₃
Storage	Desiccate at -20°C
Purity	≥98% (HPLC)
CAS Number	58493-49-5
PubChem ID	5311093
InChi Key	OPZKBPQVWDSATI-KHPPLWFESA-N
Smiles	CCCCCCCC\C=C/CCCCCCCC(=O)NCC1=CC=C(O)C(OC)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility

	Solvent	Max Conc. mM
Solubility
	DMSO	100
	ethanol	25

Preparing Stock Solutions

The following data is based on the product molecular weight 417.63.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.39 mL	11.97 mL	23.94 mL
5 mM	0.48 mL	2.39 mL	4.79 mL
10 mM	0.24 mL	1.20 mL	2.39 mL
50 mM	0.05 mL	0.24 mL	0.48 mL

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References

References are publications that support the biological activity of the product.

Di Marzo Interactions between synthetic vanilloids and the endogenous cannabinoid system. FEBS Lett. 1998 PMID: 9801167
Dray NE-19550 and NE-21610, antinociceptive capsaicin analogues: studies on nociceptive fibres of the neonatal rat tail in vitro. Eur.J.Pharmacol. 1990 PMID: 2384136
Janusz Vanilloids. 1. Analogs of capsaicin with antinociceptive and antiinflammatory activity. J.Med.Chem. 1993 PMID: 8410971
Ralevic Cannabinoid activation of recombinant and endogenous vanilloid receptors. Eur.J.Pharmacol. 2001 PMID: 11672565

Citations (1)

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Citations are publications that use Bio-Techne products. Selected citations for Olvanil include:

Witte et al. (2002) Use of a fluorescent imaging plate reader--based calcium assay to assess pharmacological differences between the human and rat vanilloid receptor. Am J Physiol Endocrinol Metab. 7:466
PMID: 14599363

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Product Datasheets

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Olvanil

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