Olvanil
Tocris Bioscience, part of Bio-Techne | Catalog # 0934
Potent TRPV agonist
Key Product Details
Description
Potent TRPV agonist
Alternative Names
NE 19550
Product Description
Olvanil is a potent vanilloid receptor agonist (pEC50 values are 8.1 and 7.7 at rat and human VR1 receptors respectively). Also blocks anandamide uptake (IC50 = 9 μM) and may bind to CB1 cannabinoid receptors. Antinociceptive following systemic administration.Product Specifications
Molecular Weight
417.63
Formula
C26H43NO3
Storage
Desiccate at -20°C
Purity
≥98% (HPLC)
Chemical Name
N-Vanillyloleoylamide
CAS Number
58493-49-5
PubChem ID
5311093
InChI Key
OPZKBPQVWDSATI-KHPPLWFESA-N
SMILES
CCCCCCCC\C=C/CCCCCCCC(=O)NCC1=CC=C(O)C(OC)=C1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 100 | ||
| Ethanol | 25 |
Preparing Stock Solutions
for Olvanil
The following data is based on the product molecular weight 417.63
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.39 mL | 11.97 mL | 23.94 mL |
| 5 mM | 0.48 mL | 2.39 mL | 4.79 mL |
| 10 mM | 0.24 mL | 1.20 mL | 2.39 mL |
| 50 mM | 0.05 mL | 0.24 mL | 0.48 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Ralevic Cannabinoid activation of recombinant and endogenous vanilloid receptors. Eur.J.Pharmacol. 2001 PMID: 11672565
- Dray NE-19550 and NE-21610, antinociceptive capsaicin analogues: studies on nociceptive fibres of the neonatal rat tail in vitro. Eur.J.Pharmacol. 1990 PMID: 2384136
- Janusz Vanilloids. 1. Analogs of capsaicin with antinociceptive and antiinflammatory activity. J.Med.Chem. 1993 PMID: 8410971
- Di Marzo Interactions between synthetic vanilloids and the endogenous cannabinoid system. FEBS Lett. 1998 PMID: 9801167
Product Specific Notices for Olvanil
For research use only
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