Olomoucine

Name: Olomoucine
Brand: Tocris Bioscience
SKU: 1284

Tocris Bioscience a Bio-Techne Brand

Catalog # 1284

Citations (1)

COA / SDS

Discontinued Product

1284 has been discontinued. View all Cyclin-dependent Kinase Inhibitors products.

Key Product Details

Description:	Cdk inhibitor
Chemical Name:	6-(Benzylamino)-2-(2-hydroxyethylamino)-9-methylpurine
Molecular Weight:	298.35

View Full Technical Details for Olomoucine

Biological Activity for Olomoucine

ATP-competitive cyclin-dependent kinase (cdk) inhibitor (reported IC₅₀ values are 0.6 and 0.94 - 8 μM for cdk7 and cdk2 respectively, and >1 μM for cdk1 and cdk9. Induces cell cycle arrest at G1 in human fibroblasts.

Technical Data for Olomoucine

M. Wt	298.35
Formula	C₁₅H₁₈N₆O
Storage	Desiccate at -20°C
CAS Number	101622-51-9
PubChem ID	4592
InChi Key	GTVPOLSIJWJJNY-UHFFFAOYSA-N
Smiles	CN1C=NC2=C(NCC3=CC=CC=C3)N=C(NCCO)N=C12

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Olomoucine

Solubility

Soluble Soluble to 50 mM in ethanol

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References for Olomoucine

References are publications that support the biological activity of the product.

Jorda How selective are pharmacological inhibitors of cell-cycle-regulating cyclin-dependent kinases? J.Med.Chem. 2018 PMID: 30234987
Alessi The cyclin-dependent kinase inhibitors olomoucine and roscovitine arrest human fibroblasts in G1 phase by specific inhibition of CDK2 kinase activity. Exp.Cell.Res. 1998 PMID: 9828096
Abraham Cellular effects of olomoucine, an inhibitor of cyclin-dependent kinases. Biol.Cell 1995 PMID: 7549905
Vesely Inhibition of cyclin-dependent kinases by purine analogues. Eur.J.Biochem. 1994 PMID: 7925396

Citations for Olomoucine (1)

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Citations are publications that use Bio-Techne products. Selected citations for Olomoucine include:

Cannon et al. (2009) Association of luteinizing hormone receptor gene expression with cell cycle progression in granulosa cells. Am J Physiol Endocrinol Metab. 296:E1392
PMID: 19293332

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