Olomoucine
Tocris Bioscience, part of Bio-Techne | Catalog # 1284
Cdk inhibitor
Discontinued Product
1284 has been discontinued.
View all Cyclin-dependent Kinase Inhibitors products.
Product Description
ATP-competitive cyclin-dependent kinase (cdk) inhibitor (reported IC50 values are 0.6 and 0.94 - 8 μM for cdk7 and cdk2 respectively, and >1 μM for cdk1 and cdk9. Induces cell cycle arrest at G1 in human fibroblasts.Product Specifications
Molecular Weight
298.35
Formula
C15H18N6O
Storage
Desiccate at -20°C
Chemical Name
6-(Benzylamino)-2-(2-hydroxyethylamino)-9-methylpurine
CAS Number
101622-51-9
PubChem ID
4592
InChI Key
GTVPOLSIJWJJNY-UHFFFAOYSA-N
SMILES
CN1C=NC2=C(NCC3=CC=CC=C3)N=C(NCCO)N=C12
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| Ethanol | 50 |
Preparing Stock Solutions
for Olomoucine
The following data is based on the product molecular weight 298.35
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.5 mM | 6.70 mL | 33.52 mL | 67.04 mL |
| 2.5 mM | 1.34 mL | 6.70 mL | 13.41 mL |
| 5 mM | 0.67 mL | 3.35 mL | 6.70 mL |
| 25 mM | 0.13 mL | 0.67 mL | 1.34 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Jorda How selective are pharmacological inhibitors of cell-cycle-regulating cyclin-dependent kinases? J.Med.Chem. 2018 PMID: 30234987
- Alessi The cyclin-dependent kinase inhibitors olomoucine and roscovitine arrest human fibroblasts in G1 phase by specific inhibition of CDK2 kinase activity. Exp.Cell.Res. 1998 PMID: 9828096
- Vesely Inhibition of cyclin-dependent kinases by purine analogues. Eur.J.Biochem. 1994 PMID: 7925396
- Abraham Cellular effects of olomoucine, an inhibitor of cyclin-dependent kinases. Biol.Cell 1995 PMID: 7549905
Product Specific Notices for Olomoucine
For research use only
Loading...
Loading...