Oligomycin A

Name: Oligomycin A
Brand: Tocris Bioscience
SKU: 4110
Rating: 4 (1 reviews)

Tocris Bioscience a Bio-Techne Brand

Catalog # 4110

Citations (3)

(1)

COA / SDS

Catalog #

Availability

Size / Price

Qty

Key Product Details

Description:	Inhibitor of mitochondrial ATPase
Chemical Name:	(1R,4E,5'S,6S,6'S,7R,8S,10R,11R, 12S,14R,15S,16R,18E,20E,22R,25S,27R,28S,29R)-22-ethyl-7,11,14,15-tetrahydroxy-6'-[(2R)-2-hydroxypropyl]-5',6,8,10,12,14,16,28,29-nonamethyl-3',4',5',6'-tetrahydro-3H,9H,13H-spiro[2,26-dioxabicyclo[23.3.1]nonacosa-4,18,20-triene-27,2'-pyran]-3,9,13-trione
Purity:	≥98% (HPLC)
Molecular Weight:	791.06

View Full Technical Details for Oligomycin A

Biological Activity for Oligomycin A

Oligomycin A is an inhibitor of mitochondrial ATP synthase and uncoupler of oxidative phosphorylation. Antibiotic; exhibits anti-tumor activity.

Technical Data for Oligomycin A

M. Wt	791.06
Formula	C₄₅H₇₄O₁₁
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	579-13-5
PubChem ID	5281899
InChi Key	MNULEGDCPYONBU-WMBHJXFZSA-N
Smiles	CC[C@](CC[C@@]([H])(O[C@@]2(CC[C@@H](C)[C@@]([H])(C[C@@H](O)C)O2)[C@@H]1C)[C@H](C)[C@]1([H])OC(/C=C/[C@H]([C@@H]([C@@H](C)C([C@@H](C)[C@H](O)[C@H]3C)=O)O)C)=O)([H])/C=C/C=C/C[C@H](C)[C@@H](O)[C@](C)(O)C3=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Oligomycin A

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	ethanol	7.91	10

Preparing Stock Solutions for Oligomycin A

The following data is based on the product molecular weight 791.06.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	12.64 mL	63.21 mL	126.41 mL
0.5 mM	2.53 mL	12.64 mL	25.28 mL
1 mM	1.26 mL	6.32 mL	12.64 mL
5 mM	0.25 mL	1.26 mL	2.53 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

Mass

Concentration

Volume

M. Wt*

g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Concentration 1 (C1)

Volume 1 (V1)

Concentration 2 (C2)

Volume 2 (V2)

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

Volume (to add to vial)

Mass (in vial)

Desired Reconstitution Concentration

References for Oligomycin A

References are publications that support the biological activity of the product.

Salomon Apoptolidin, a selective cytotoxic agent, is an inhibitor of F₀F₁-ATPase. Chem.Biol. 2001 PMID: 11182320

Citations for Oligomycin A (3)

Showing 1 - 3 of 3 citations Showing All

Search Title:

Citations are publications that use Bio-Techne products. Selected citations for Oligomycin A include:

Depaoli et al. (2018) Real-Time Imaging of Mitochondrial ATP Dynamics Reveals the Metabolic Setting of Single Cells. Cell Rep. 25:501
PMID: 30304688
Shin et al. (2017) Lipolysis in Brown Adipocytes Is Not Essential for Cold-Induced Thermogenesis in Mice. Cell Metab. 26:764
PMID: 28988822
Banh et al. (2016) PTP1B controls non-mitochondrial oxygen consumption by regulating RNF213 to promote tumour survival during hypoxia. Nat Cell Biol. 18:803
PMID: 27323329

There are no citations that match your criteria.

Showing 1 - 3 of 3 citations Showing All

Customer Reviews for Oligomycin A (1)

4 out of 5

1 customer rating

5 stars

4 stars

100%

3 stars

2 stars

1 star

Customer Images

Showing 1 - 1 of 1 review Showing All

Filter By:

Oligomycin A was used in oxidative phosphorylation studies

Name: Jade Smith

Species: Mouse

Assay Type: In Vivo

Oligomycin A was used in oxidative phosphorylation studies. Its action on protein channel blocking was being studied. Performed well and gives repeatable results.

There are no reviews that match your criteria.