OGT 2115

Name: OGT 2115
Brand: Tocris Bioscience
SKU: 2710

Tocris Bioscience, part of Bio-Techne | Catalog # 2710

Citations (37)

COA / SDS

Antiangiogenic. Heparanase inhibitor

Key Product Details

Description:	Antiangiogenic. Heparanase inhibitor
Chemical Name:	2-[4-[[3-(4-Bromophenyl)-1-oxo-2-propenyl]amino]-3-fluorophenyl]-5-benzoxazoleacetic acid
Purity:	≥97% (HPLC)
Molecular Weight:	495.3

View Full Technical Details for OGT 2115

Technical Data
Citations

Biological Activity for OGT 2115

OGT 2115 is a heparanase inhibitor (IC₅₀ = 0.4 μM) that displays no major inhibition of human cytochrome P450 isoenzymes (IC₅₀ > 30 μM). Exhibits antiangiogenic properties in vitro (IC₅₀ = 1 μM).

Technical Data for OGT 2115

M. Wt	495.3
Formula	C₂₄H₁₆BrFN₂O₄
Storage	Store at RT
Purity	≥97% (HPLC)
CAS Number	853929-59-6
PubChem ID	44402523
InChi Key	LKBXWNYXDMSFQU-ONNFQVAWSA-N
Smiles	O=C(/C=C/C4=CC=C(Br)C=C4)NC(C(F)=C3)=CC=C3C2=NC1=CC(CC(O)=O)=CC=C1O2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for OGT 2115

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	4.95	10

Preparing Stock Solutions for OGT 2115

The following data is based on the product molecular weight 495.3.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	20.19 mL	100.95 mL	201.90 mL
0.5 mM	4.04 mL	20.19 mL	40.38 mL
1 mM	2.02 mL	10.09 mL	20.19 mL
5 mM	0.40 mL	2.02 mL	4.04 mL

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References for OGT 2115

References are publications that support the biological activity of the product.

Courtney Furanyl-1,3-thiazol-2-yl and benzoxazol-5-yl acetic acid derivates: novel classes of heparanase inhibitor. Bioorg.Med.Chem.Letts.
McKenzie Heparanase: a target for drug discovery in cancer and inflammation. Br.J.Pharmacol. 2007 PMID: 17339837