Ogerin
Tocris Bioscience, part of Bio-Techne | Catalog # 5722
Selective positive allosteric modulator at GPR68
Key Product Details
Description
Selective positive allosteric modulator at GPR68
Product Description
Ogerin is a selective positive allosteric modulator (PAM) of GPR68 (pEC50 = 6.83), which exhibits selectivity for GPR68 over 58 other GPCRs. Ogerin attenuates contextual-based fear memory in mice.External Portal Information
Chemicalprobes.org and the Chemical Probes webpages of the Structural Genomics Consortium are portals that offer independent guidance on the selection and/or application of small molecules for research. The use of Ogerin is reviewed on chemicalprobes.org and the SGC website.Product Specifications
Molecular Weight
307.35
Formula
C17H17N5O
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
2-[4-Amino-6-[(phenylmethyl)amino]-1,3,5-triazin-2-yl]benzenemethanol
CAS Number
1309198-71-7
PubChem ID
56707820
InChI Key
MDGIEDNDSFMSLP-UHFFFAOYSA-N
SMILES
NC1=NC(NCC2=CC=CC=C2)=NC(C3=CC=CC=C3CO)=N1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 30.73 | 100 | |
| Ethanol | 6.15 | 20 |
Preparing Stock Solutions
for Ogerin
The following data is based on the product molecular weight 307.35
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.25 mL | 16.27 mL | 32.54 mL |
| 5 mM | 0.65 mL | 3.25 mL | 6.51 mL |
| 10 mM | 0.33 mL | 1.63 mL | 3.25 mL |
| 50 mM | 0.07 mL | 0.33 mL | 0.65 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Huang Allosteric ligands for the pharmacologically dark receptors GPR68 and GPR65. Nature 2015 PMID: 26550826
Product Specific Notices for Ogerin
For research use only
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