Key Product Details
Description: | Selective inhibitor of NO-sensitive guanylyl cyclase |
Chemical Name: | 1H-[1,2,4]Oxadiazolo[4,3-a]quinoxalin-1-one |
Purity: | ≥99% (HPLC) |
Molecular Weight: | 187.16 |
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Citations for ODQ (48)
Citations are publications that use Bio-Techne products. Selected citations for ODQ include:
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Cameron
(2017)
Structural and pharmacological basis for the induction of mitochondrial biogenesis by formo. but not clenbu.
Sci Rep.
7(1):10578
PMID: 28874749 -
Manchope et al.
(2016)
Naringenin Inhibits Superoxide Anion-Induced Inflammatory Pain: Role of Oxidative Stress, Cytokines, Nrf-2 and the NO-cGMP-PKG-KATP Channel Signaling Pathway.
PLoS One.
11:e0153015
PMID: 27045367 -
Yuan et al.
(2015)
Protein kinase G-regulated production of H2S governs oxygen sensing.
Sci Signal.
8:ra37
PMID: 25900831 -
Padovan-Neto et al.
(2015)
Facilitation of corticostriatal transmission following pharmacological inhibition of striatal phosphodiesterase 10A: role of nitric oxide-soluble guanylyl cyclase-cGMP signaling pathways.
Mol Cell Neurosci.
35:5781
PMID: 25855188 -
Garthwaite et al.
(2015)
Nitric oxide targets oligodendrocytes and promotes their morphological differentiation.
Braz J Med Biol Res.
63:383
PMID: 25327839 -
Galdino et al.
(2015)
Central release of nitric oxide mediates antinociception induced by aerobic exercise.
Proc Natl Acad Sci U S A.
48:790
PMID: 25517916 -
Wallace et al.
(2015)
Regulation of nerve-evoked contractions of rabbit vas deferens by acetylcholine.
Proc Natl Acad Sci U S A.
3
PMID: 26359240 -
Bice et al.
(2014)
NO-independent stimulation or activation of soluble guanylyl cyclase during early reperfusion limits infarct size.
Cardiovasc Res.
101:220
PMID: 24259501 -
Ho et al.
(2013)
Caffeic acid phenethyl amide improves glucose homeostasis and attenuates the progression of vascular dysfunction in Streptozotocin-induced diabetic rats.
Cardiovasc Diabetol.
12:99
PMID: 23829275 -
Fakira et al.
(2012)
Purkinje cell dysfunction and delayed death in plasma membrane calcium ATPase 2-heterozygous mice.
Glia.
51:22
PMID: 22789621 -
Tseng et al.
(2011)
Inhibition of striatal soluble guanylyl cyclase-cGMP signaling reverses basal ganglia dysfunction and akinesia in experimental parkinsonism.
PLoS One.
6:e27187
PMID: 22073284 -
Chester et al.
(2011)
Cinaciguat, a soluble guanylate cyclase activator, augments cGMP after oxidative stress and causes pulmonary vasodilation in neonatal pulmonary hypertension.
J Neurosci.
301:L755
PMID: 21856817 -
Harnek et al.
(2011)
Intimal hyperplasia in balloon dilated coronary arteries is reduced by local delivery of the NO donor, SIN-1 via a cGMP-dependent pathway.
Exp Mol Med.
11:30
PMID: 21663688 -
Moonen and Villamor
(2011)
Developmental changes in mesenteric artery reactivity in embryonic and newly hatched chicks.
J Comp Physiol B.
181:1063
PMID: 21626136 -
Yoo et al.
(2010)
Inhibition of hypoxic pulmonary vasoconstriction of rats by carbon monoxide.
J Korean Med Sci.
25:1411
PMID: 20890419 -
Huang and Hsu
(2010)
Activation of muscarinic acetylcholine receptors induces a nitric oxide-dependent long-term depression in rat medial prefrontal cortex.
Cereb Cortex.
20:982
PMID: 19666830 -
Suri et al.
(2010)
Quercetin and its major metabolites selectively modulate cyclic GMP-dependent relaxations and associated tolerance in pig isolated coronary artery.
Br J Pharmacol.
159:566
PMID: 20050852 -
Chester et al.
(2009)
Cinaciguat, a soluble guanylate cyclase activator, causes potent and sustained pulmonary vasodilation in the ovine fetus.
Am J Physiol Lung Cell Mol Physiol.
297:L318
PMID: 19465519 -
Hoffmann et al.
(2009)
Distinct molecular requirements for activation or stabilization of soluble guanylyl cyclase upon haem oxidation-induced degradation.
Br J Pharmacol.
157:781
PMID: 19466990 -
Anselm et al.
(2007)
Grape juice causes endothelium-dependent relaxation via a redox-sensitive Src- and Akt-dependent activation of eNOS.
Cardiovasc Res.
73:404
PMID: 16962569 -
Newman et al.
(2007)
Endocannabinoids mediate muscarine-induced synaptic depression at the vertebrate neuromuscular junction.
Eur J Neurosci.
25:1619
PMID: 17408433 -
Dalsgaard et al.
(2007)
Nitrite-dependent vasodilation is facilitated by hypoxia and is independent of known NO-generating nitrite reductase activities.
Am J Physiol Heart Circ Physiol.
292:H3072
PMID: 17307993 -
Makara et al.
(2007)
Involvement of nitric oxide in depolarization-induced suppression of inhibition in hippocampal pyramidal cells during activation of cholinergic receptors.
J Neurosci.
27:10211
PMID: 17881527 -
Ågren et al.
(2007)
Ontogeny of chicken ductus arteriosus response to oxygen and vasoconstrictors.
Am J Physiol Regul Integr Comp Physiol.
292:R485
PMID: 16917023 -
Yang
(2007)
Modulation of inhibitory activity by nitric oxide in the thalamus.
J Neurophysiol.
97:3386
PMID: 17376843 -
McNeish et al.
(2006)
Evidence for involvement of both IKCa and SKCa channels in hyperpolarizing responses of the rat middle cerebral artery.
BMC Cardiovasc Disord.
37:1277
PMID: 16556879 -
Cauwels et al.
(2006)
Anaphylactic shock depends on PI3K and eNOS-derived NO.
J Clin Invest.
116:2244
PMID: 16886062 -
Namkoong et al.
(2005)
Prostaglandin E2 stimulates angiogenesis by activating the nitric oxide/cGMP pathway in human umbilical vein endothelial cells.
J Pharmacol Exp Ther.
37:588
PMID: 16391520 -
Sachs et al.
(2004)
Peripheral analgesic blockade of hypernociception: activation of arginine/NO/cGMP/protein kinase G/ATP-sensitive K+ channel pathway.
Proc Natl Acad Sci U S A.
101:3680
PMID: 14990791 -
Cirino et al.
(2003)
Involvement of β 3-adrenergic receptor activation via cyclic GMP- but not NO-dependent mechanisms in human corpus cavernosum function.
Am J Physiol Lung Cell Mol Physiol.
100:5531
PMID: 12707413 -
Tsang et al.
(2003)
Contribution of Na+ -Ca2+ exchanger to pinacidil-induced relaxation in the rat mesenteric artery.
Br J Pharmacol.
138:453
PMID: 12569070 -
Bellamy and Garthwaite
(2002)
Pharmacology of the nitric oxide receptor, soluble guanylyl cyclase, in cerebellar cells.
Br J Pharmacol.
136:95
PMID: 11976273 -
Villamor et al.
(2002)
Vascular reactivity in intrapulmonary arteries of chicken embryos during transition to ex ovo life.
Am J Physiol Regul Integr Comp Physiol.
282:R917
PMID: 11832415 -
Stanford et al.
(2001)
Identification of two distinct vasodilator pathways activated by ATP in the mesenteric bed of the rat.
Br J Pharmacol.
133:825
PMID: 11454655 -
Dick et al.
(2000)
Investigation of the interaction between nitric oxide and vasoactive intestinal polypeptide in the guinea-pig gastric fundus.
Br J Pharmacol.
129:751
PMID: 10683200 -
Hedlund et al.
(2000)
Erectile dysfunction in cyclic GMP-dependent kinase I-deficient mice.
Physiol Rep.
97:2349
PMID: 10688876 -
Casado et al.
(2000)
Presynaptic N-MthD.-aspartate receptors at the parallel fiber-Purkinje cell synapse.
Stroke.
97:11593
PMID: 11016958 -
Mundey et al.
(2000)
Pharmacological characterization of neurogenic responses of the sheep isolated internal anal sphincter.
Br J Pharmacol.
130:489
PMID: 10821775 -
Haynes
(2000)
A(2A) adenosine receptor mediated potassium channel activation in rat epididymal smooth muscle.
Br J Pharmacol.
130:685
PMID: 10821799 -
Pérez-Vizcaíno et al.
(1999)
Vasodilator effects of sodium nitroprusside, levcromakalim and their combination in isolated rat aorta.
Br J Pharmacol.
128:1419
PMID: 10602320 -
Cogolludo et al.
(1999)
Effects of nicorandil as compared to mixtures of sodium nitroprusside and levcromakalim in isolated rat aorta.
Br J Pharmacol.
126:1025
PMID: 10193784 -
Aszódi et al.
(1999)
The vasodilator-stimulated phosphoprotein (VASP) is involved in cGMP- and cAMP-mediated inhibition of agonist-induced platelet aggregation, but is dispensable for smooth muscle function.
EMBO J.
18:37
PMID: 9878048 -
Villarroya et al.
(1999)
PF9404C, a new slow NO donor with beta receptor blocking properties.
Br J Pharmacol.
128:1713
PMID: 10588927 -
Rach et al.
(1999)
Deficiency in myocardial NO biosignalling after cardiop. arrest: mechanisms and contribution to post-storage mechanical dysfunction.
Br J Pharmacol.
128:891
PMID: 10556923 -
Ruiz and Tejerina
(1998)
Relaxant effects of L-citrulline in rabbit vascular smooth muscle.
Br J Pharmacol.
125:186
PMID: 9776359 -
Prieto et al.
(1998)
Contribution of K+ channels and ouabain-sensitive mechanisms to the endothelium-dependent relaxations of horse penile small arteries.
Br J Pharmacol.
123:1609
PMID: 9605568 -
Fonseca et al.
(1998)
No evidence for a significant non-nitrergic, hyperpolarising factor contribution to field stimulation-induced relaxation of the mouse anococcygeus.
Br J Pharmacol.
124:524
PMID: 9647477 -
Fedele et al.
(1996)
In vivo microdialysis study of a specific inhibitor of soluble guanylyl cyclase on the glutamate receptor/nitric oxide/cyclic GMP pathway.
Br J Pharmacol.
119:590
PMID: 8894183
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