OB-1
Tocris Bioscience, part of Bio-Techne | Catalog # 6545
Stomatin-like protein-3 (STOML3) oligomerization inhibitor
Key Product Details
Description
Stomatin-like protein-3 (STOML3) oligomerization inhibitor
Product Description
OB-1 is a stomatin-like protein-3 (STOML3) oligomerization inhibitor. Reduces STOML3 cluster size in the plasma membrane. Decreases mechanically-induced Piezo1 but not ASIC3 current amplitudes in N2a cells and cultured mouse sensory neurons in vitro. Subcutaneous administration in mice reversibly silences touch receptor activity and inhibits paw withdrawal reflex in a mouse neuropathic pain model.Product Specifications
Molecular Weight
407.38
Formula
C21H17N3O6
Storage
Store at RT
Purity
≥98% (HPLC)
Chemical Name
Ethyl 5-(1-methyl-4-nitro-1H-imidazol-5-yloxy)-2-phenylbenzofuran-3-carboxylate
CAS Number
300803-69-4
PubChem ID
1113704
InChI Key
UJHGRDVYTTVJFD-UHFFFAOYSA-N
SMILES
CCOC(C1=C(C2=CC=CC=C2)OC3=CC=C(C=C13)OC4=C([N+]([O-])=O)N=CN4C)=O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 20.37 | 50 |
Preparing Stock Solutions
for OB-1
The following data is based on the product molecular weight 407.38
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.5 mM | 4.91 mL | 24.55 mL | 49.09 mL |
| 2.5 mM | 0.98 mL | 4.91 mL | 9.82 mL |
| 5 mM | 0.49 mL | 2.45 mL | 4.91 mL |
| 25 mM | 0.10 mL | 0.49 mL | 0.98 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Wetzel Small-molecule inhibition of STOML3 oligomerization reverses pathological mechanical hypersensitivity. Nat.Neurosci. 2017 PMID: 27941788
Product Specific Notices for OB-1
For research use only
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