NVS PAK1 1
Tocris Bioscience, part of Bio-Techne | Catalog # 6132
Potent and selective PAK1 inhibitor
Product Description
NVS PAK1 1 is a potent and selective PAK1 inhibitor (IC50 = 5 nM) that displays selective for PAK1 over PAK2 and a panel of 442 kinases. NVS PAK1 1 inhibits autophosphorylation of PAK1 in KRAS-mutated pancreatic cancer cell lines.A negative control for NVS PAK1 1 is also available; NVS PAK1 C.
Licensing Information
This probe is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the NVS-PAK1-1 probe summary on the SGC website.External Portal Information
Chemicalprobes.org is a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of NVS-PAK1-1 is reviewed on the chemical probes website.Product Specifications
Molecular Weight
479.93
Formula
C23H25ClF3N5O
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
(3S)-3-(2-Chloro-5-(2,2-difluoroethyl)-8-fluoro-5H-dibenzo[b,e][1,4]diazepin-11-ylamino)-N-isopropylpyrrolidine-1-carboxamide
CAS Number
1783816-74-9
PubChem ID
122187564
InChI Key
OINGHOPGNMYCAB-INIZCTEOSA-N
SMILES
FC(F)CN(C(C=CC(F)=C1)=C1N=C2N[C@H]3CCN(C(NC(C)C)=O)C3)C4=C2C=C(Cl)C=C4
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| 1eq. HCl | 47.99 | 100 | |
| DMSO | 47.99 | 100 |
Preparing Stock Solutions
for NVS PAK1 1
The following data is based on the product molecular weight 479.93
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.08 mL | 10.42 mL | 20.84 mL |
| 5 mM | 0.42 mL | 2.08 mL | 4.17 mL |
| 10 mM | 0.21 mL | 1.04 mL | 2.08 mL |
| 50 mM | 0.04 mL | 0.21 mL | 0.42 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Karpov Optimization of a dibenzodiazepine hit to a potent and selective allosteric PAK1 inhibitor. ACS Med.Chem.Lett. 2015 PMID: 26191365
Product Specific Notices for NVS PAK1 1
For research use only
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