NVS-CECR2-1

Name: NVS-CECR2-1
Brand: Tocris Bioscience
SKU: 5744

Tocris Bioscience, part of Bio-Techne | Catalog # 5744

Citations (3)

COA / SDS

Potent and selective CECR2 inhibitor

Key Product Details

Description:	Potent and selective CECR2 inhibitor
Chemical Name:	N-Cyclopropyl-2-(propylsulfonyl)-6-(1-(2,2,6,6-tetramethylpiperidin-4-yl)-1H-indol-5-yl)pyrimidin-4-amine
Purity:	≥98% (HPLC)
Molecular Weight:	495.68

View Full Technical Details for NVS-CECR2-1

Technical Data
Citations

Biological Activity for NVS-CECR2-1

NVS-CECR2-1 is a potent and selective CECR2 (cat eye syndrome chromosome region, candidate 2) inhibitor (IC₅₀ = 47 nM). Selective for CECR2 over a panel of bromodomains.

A concentration of 1 μM is recommended for use in cellular assays.

Licensing Information

This probe is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the NVS-CECR2-1 probe summary on the SGC website.

Compound Libraries for NVS-CECR2-1

NVS-CECR2-1 is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Epigenetics Library. Find out more about compound libraries available from Tocris.

Technical Data for NVS-CECR2-1

M. Wt	495.68
Formula	C₂₇H₃₇N₅O₂S
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	1992047-61-6
PubChem ID	117072550
InChi Key	XVECNLUKQDKOST-UHFFFAOYSA-N
Smiles	CC(C1)(C)NC(C)(C)CC1N2C=CC3=C2C=CC(C4=NC(S(=O)(CCC)=O)=NC(NC5CC5)=C4)=C3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for NVS-CECR2-1

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	49.57	100

Preparing Stock Solutions for NVS-CECR2-1

The following data is based on the product molecular weight 495.68.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.02 mL	10.09 mL	20.17 mL
5 mM	0.40 mL	2.02 mL	4.03 mL
10 mM	0.20 mL	1.01 mL	2.02 mL
50 mM	0.04 mL	0.20 mL	0.40 mL

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Product Documents for NVS-CECR2-1

COA

Certificate of Analysis

To download a Certificate of Analysis, please select a batch below.