NVP 231
Tocris Bioscience, part of Bio-Techne | Catalog # 3960
Potent, selective and reversible CerK inhibitor
Key Product Details
Description
Potent, selective and reversible CerK inhibitor
Product Description
NVP 231 is a potent, selective and reversible ceramide kinase (CerK) inhibitor (IC50 = 12 nM in vitro). Displays selectivity for CerK over sphingosine kinases (IC50 ≥100 μM) and other lipid kinases.Product Specifications
Molecular Weight
431.55
Formula
C25H25N3O2S
Storage
Store at +4°C
Purity
≥98% (HPLC)
Chemical Name
N-[2-(Benzoylamino)-6-benzothiazolyl]tricyclo[3.3.1.13,7]decane-1-carboxamide
CAS Number
362003-83-6
PubChem ID
4096211
InChI Key
MVSSJPGNLQPWSW-UHFFFAOYSA-N
SMILES
O=C(C3=CC=CC=C3)NC2=NC(C=C1)=C(S2)C=C1NC(C45CC(C6)CC(CC6C5)C4)=O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 43.16 | 100 | |
| Ethanol | 2.16 | 5 |
Preparing Stock Solutions
for NVP 231
The following data is based on the product molecular weight 431.55
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.32 mL | 11.59 mL | 23.17 mL |
| 5 mM | 0.46 mL | 2.32 mL | 4.63 mL |
| 10 mM | 0.23 mL | 1.16 mL | 2.32 mL |
| 50 mM | 0.05 mL | 0.23 mL | 0.46 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Niwa Ceramide kinase deficiency impairs microendothelial cell angiogenesis in vitro. Microvasc.Res. 2009 PMID: 19323974
- Graf Targeting ceramide metabolism with a potent and specific ceramide kinase inhibitor. Mol.Pharmacol. 2009 PMID: 18612076
- Graf A secondary assay for ceramide kinase inhibitors based on cell growth inhibition by short-chain ceramides. Anal.Biochem. 2009 PMID: 18831956
Product Specific Notices for NVP 231
For research use only
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