NU 6140

Name: NU 6140
Brand: Tocris Bioscience
SKU: 3301

Tocris Bioscience, part of Bio-Techne | Catalog # 3301

Citations (17)

COA / SDS

Cdk2 inhibitor; also potent inhibitor of aurora kinase A and B

Key Product Details

Description:	Cdk2 inhibitor; also potent inhibitor of aurora kinase A and B
Chemical Name:	4-[[6-(Cyclohexylmethoxy)-1H-purin-2-yl]amino]-N,N-diethylbenzamide
Purity:	≥98% (HPLC)
Molecular Weight:	422.52

View Full Technical Details for NU 6140

Technical Data
Citations

Biological Activity for NU 6140

NU 6140 is a cyclin-dependent kinase 2 (cdk2) inhibitor (IC₅₀ values are 0.42 - 1.1 μM). Displays some selectivity for cdk2 (IC₅₀ value = 0.94 μM for cdk4 and >2.3 μM for other cdks). Induces cell-cycle arrest at the G2-M phase. Potentiates the apoptotic effect of taxol (Cat. No. 1097) in HeLa cells; down-regulates the antiapoptotic protein survivin. Also potently inhibits aurora kinases (IC₅₀ values are 0.035 and 0.067 μM for aurora kinase B and A, respectively).

Compound Libraries for NU 6140

NU 6140 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for NU 6140

M. Wt	422.52
Formula	C₂₃H₃₀N₆O₂
Storage	Desiccate at +4°C
Purity	≥98% (HPLC)
CAS Number	444723-13-1
PubChem ID	10202471
InChi Key	XHEQSRJCJTWWAH-UHFFFAOYSA-N
Smiles	O=C(N(CC)CC)C(C=C4)=CC=C4NC1=NC(NC=N2)=C2C(OCC3CCCCC3)=N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for NU 6140

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	42.25	100
	ethanol	42.25	100

Preparing Stock Solutions for NU 6140

The following data is based on the product molecular weight 422.52.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.37 mL	11.83 mL	23.67 mL
5 mM	0.47 mL	2.37 mL	4.73 mL
10 mM	0.24 mL	1.18 mL	2.37 mL
50 mM	0.05 mL	0.24 mL	0.47 mL

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References for NU 6140

References are publications that support the biological activity of the product.

Jorda How selective are pharmacological inhibitors of cell-cycle-regulating cyclin-dependent kinases? J.Med.Chem. 2018 PMID: 30234987
Pennati Potentiation of PacT.-induced apoptosis by the novel cyclin-dependent kinase inhibitor NU6140: a possible role for survivin down-regulation. Mol.Cancer.Ther. 2005 PMID: 16170024