NSC 668036
Tocris Bioscience, part of Bio-Techne | Catalog # 5813
Wnt signaling inhibitor; binds the PDZ domain of the Dishevelled (Dvl) protein
Key Product Details
Description
Wnt signaling inhibitor; binds the PDZ domain of the Dishevelled (Dvl) protein
Product Description
NSC 668036 is a Wnt signaling inhibitor. Binds the PDZ domain of the Dishevelled (Dvl) protein. Inhibits proliferation, migration and TGF-β-induced differentiation of fibroblasts in vitro. Reduces severity of pulmonary fibrosis in a mouse model.Product Specifications
Molecular Weight
460.52
Formula
C21H36N2O9
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
N-[(1,1-dimethylethoxy)carbonyl]-L-alanyl-(2S)-2-hydroxy-3-methylbutanoyl-L-alanine-(1S)-1-carboxy-2-methylpropyl ester
CAS Number
144678-63-7
PubChem ID
71312060
InChI Key
IPICFSFUAKDZEI-AJNGGQMLSA-N
SMILES
CC([C@@H](C(O)=O)OC([C@@H](NC([C@H](C(C)C)OC([C@@H](NC(OC(C)(C)C)=O)C)=O)=O)C)=O)C
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 46.05 | 100 | |
| Ethanol | 46.05 | 100 |
Preparing Stock Solutions
for NSC 668036
The following data is based on the product molecular weight 460.52
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.17 mL | 10.86 mL | 21.71 mL |
| 5 mM | 0.43 mL | 2.17 mL | 4.34 mL |
| 10 mM | 0.22 mL | 1.09 mL | 2.17 mL |
| 50 mM | 0.04 mL | 0.22 mL | 0.43 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Wang Targeted inhibition of disheveled PDZ domain via NSC668036 depresses fibrotic process. Exp.Cell Res. 2015 PMID: 25445788
- Shan Identification of a specific inhibitor of the dishevelled PDZ domain. Biochemistry 2005 PMID: 16300398
Product Specific Notices for NSC 668036
For research use only
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