NSC 624206
Tocris Bioscience, part of Bio-Techne | Catalog # 4993
Ubiquitin-activating enzyme (E1) inhibitor
Key Product Details
Description
Ubiquitin-activating enzyme (E1) inhibitor
Product Description
NSC 624206 is an ubiquitin-activating enzyme (E1) inhibitor; prevents tumour suppressor protein p27 ubiquitination in vitro. Blocks the ubiquitin-thioester formation step of the E1 activation reaction, but displays no effect on ubiquitin adenylation.Product Specifications
Molecular Weight
410.51
Formula
C19H32ClNS2.HCl
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
N-[2-[[(4-Chlorophenyl)methyl]dithio]ethyl]-1-decanamine hydrochloride
CAS Number
13116-77-3
PubChem ID
361263
InChI Key
JQHUAYXPNPTQRO-UHFFFAOYSA-N
SMILES
ClC1=CC=C(CSSCCNCCCCCCCCCC)C=C1.Cl
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 20.53 | 50 | |
| Ethanol | 8.21 | 20 |
Preparing Stock Solutions
for NSC 624206
The following data is based on the product molecular weight 410.51
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.5 mM | 4.87 mL | 24.36 mL | 48.72 mL |
| 2.5 mM | 0.97 mL | 4.87 mL | 9.74 mL |
| 5 mM | 0.49 mL | 2.44 mL | 4.87 mL |
| 25 mM | 0.10 mL | 0.49 mL | 0.97 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Ungermannova Identification and mechanistic studies of a novel ubiquitin E1 inhibitor. J.Biomol.Screen. 2012 PMID: 22274912
Product Specific Notices for NSC 624206
For research use only
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