NSC 617145
Tocris Bioscience, part of Bio-Techne | Catalog # 5340
Werner syndrome helicase (WRN) inhibitor
Key Product Details
Description
Werner syndrome helicase (WRN) inhibitor
Product Description
NSC 617145 is a werner syndrome helicase (WRN) helicase inhibitor (IC50 = 250 nM); acts synergistically with Mitomycin C (Cat. No. 3258) to induce double-strand breaks and chromosomal abnormalities in vitro.Product Specifications
Molecular Weight
400.04
Formula
C13H10Cl4N2O4
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
1,1'-(2,2-Dimethyl-1,3-propanediyl)bis[3,4-dichloro-1H-pyrrole-2,5-dione
CAS Number
203115-63-3
PubChem ID
357621
InChI Key
PCOXPBOKDABARQ-UHFFFAOYSA-N
SMILES
CC(CN1C(C(Cl)=C(Cl)C1=O)=O)(C)CN2C(C(Cl)=C(Cl)C2=O)=O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 8 | 20 |
Preparing Stock Solutions
for NSC 617145
The following data is based on the product molecular weight 400.04
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.2 mM | 12.50 mL | 62.49 mL | 124.99 mL |
| 1 mM | 2.50 mL | 12.50 mL | 25.00 mL |
| 2 mM | 1.25 mL | 6.25 mL | 12.50 mL |
| 10 mM | 0.25 mL | 1.25 mL | 2.50 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Aggarwal Targeting an Achilles' heel of cancer with a WRN helicase inhibitor. Cell Cycle 2013 PMID: 24036544
- Aggarwal Werner syndrome helicase has a critical role in DNA damage responses in the absence of a functional fanconi anemia pathway. Cancer Res. 2013 PMID: 23867477
Product Specific Notices for NSC 617145
For research use only
Loading...
Loading...