NSC 405020

Name: NSC 405020
Brand: Tocris Bioscience
SKU: 4902

Tocris Bioscience a Bio-Techne Brand

Catalog # 4902

Citations (2)

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Key Product Details

Description:	Histone deacetylase inhibitor
Chemical Name:	3,4-Dichloro-N-(1-methylbutyl)benzamide
Purity:	≥99% (HPLC)
Molecular Weight:	260.16

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Biological Activity for NSC 405020

NSC 405020 is a membrane type-1 matrix metalloproteinase (MT1-MMP) inhibitor (IC₅₀ > 100 μmol/L). Directly interacts with the hemopexin domain (PEX) of MT1-MMP, affecting homodimerization and repressing its pro-tumorigenic activity in vivo. Displays no effect on the catalytic activity of MT1-MMP or MMP-2.

Compound Libraries for NSC 405020

NSC 405020 is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Antiviral Library. Find out more about compound libraries available from Tocris.

Technical Data for NSC 405020

M. Wt	260.16
Formula	C₁₂H₁₅Cl₂NO
Storage	Store at RT
Purity	≥99% (HPLC)
CAS Number	7497-07-6
PubChem ID	346721
InChi Key	ARDYECYBETXQFD-UHFFFAOYSA-N
Smiles	ClC1=CC=C(C(NC(C)CCC)=O)C=C1Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for NSC 405020

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	26.02	100
	ethanol	26.02	100

Preparing Stock Solutions for NSC 405020

The following data is based on the product molecular weight 260.16.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.84 mL	19.22 mL	38.44 mL
5 mM	0.77 mL	3.84 mL	7.69 mL
10 mM	0.38 mL	1.92 mL	3.84 mL
50 mM	0.08 mL	0.38 mL	0.77 mL

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References for NSC 405020

References are publications that support the biological activity of the product.

Remacle Novel MT1-MMP small-molecule inhibitors based on insights into hemopexin domain function in tumor growth. Cancer Res. 2012 PMID: 22406620

Citations for NSC 405020 (2)

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Citations are publications that use Bio-Techne products. Selected citations for NSC 405020 include:

Kumar et al. (2018) MMP Secretion Rate and Inter-invadopodia Spacing Collectively Govern Cancer Invasiveness. Biophys J. 114:650
PMID: 29414711
Clancy et al. (2015) Regulated delivery of molecular cargo to invasive tumour-derived microvesicles. Proc Natl Acad Sci U S A. 6:6919
PMID: 25897521

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